Resveratrol and derived molecules were for a time excessively hyped as a means to trigger some of the beneficial metabolic response produced by calorie restriction, by acting on sirtuins, and thus have a positive impact on aging. The company Sirtris was founded to develop this area of research into a therapeutic, its backers did a great deal to promote the aforementioned excessive hype, the...
The name Lonza comes from the river in Switzerland near where the company was originally founded more than a hundred years ago, As such, it has nothing to do with the biomedical products and services that Lonza provides. Lonza is active around the world and has around 15,000 employees with branches in the Netherlands as...
The key to a universal cancer therapy is to find a vulnerability that is (a) common to all cancers, something fundamental to cancer as a class, (b) nowhere near as prevalent in normal cells, and (c) can be cost-effectively exploited as a basis for treatment. Lengthening of telomeres is a good example, and an area in which at...
Senolytic drugs are those capable of selectively destroying senescent cells. A range of such therapies are at various stages of development, including those that have reached initial human clinical trials. Senescent cell accumulation is an important cause of degenerative aging, and the removal of such cells via senolytic treatments has been shown to produce rejuvenation...
by Brigham and Women’s Hospital Credit: Pixabay/CC0 Public Domain In the past few decades, researchers have identified biological pathways leading to neurodegenerative diseases and developed promising molecular agents to target them. However, the translation of these findings into clinically approved treatments has progressed at a much slower rate, in part because of the challenges scientists face in delivering...
With increased life expectancy, age-associated cognitive decline becomes a growing concern, even in the absence of recognizable neurodegenerative disease. The integrated stress response (ISR) is activated during aging and contributes to age-related brain phenotypes. We demonstrate that treatment with the drug-like small-molecule ISR inhibitor ISRIB reverses ISR activation in the brain, as indicated by decreased...
by Public Library of Science Colorized scanning electron micrograph of an apoptotic cell (pink) heavily infected with SARS-COV-2 virus particles (green), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: National Institute of Allergy and Infectious Diseases/NIH, 2020 (CC0) A novel computational drug screening strategy combined with lab...
by UT Southwestern Medical Center A UTSW study identified a type of blood vessel cell that triggers inflammation in fat tissue. Above, inflammatory immune cells (green) surround fat cells (red) in obesity and contribute to the development of metabolic disease. Credit: UT Southwestern Medical Center Dec. 30, 2020—When fat cells in the body are stuffed with...
By Ben Coxworth December 30, 2020 Implanted into a phantom brain (left), the device successfully delivered light and a blue dye (right)Anikeeva LabVIEW 1 IMAGES When taken orally or intravenously, medications typically travel throughout the body, producing unwanted side effects. MIT scientists are working on an alternative, that delivers both light and a light-activated drug...
Axin is a VIP – a Very Important Protein. It’s essential to the development of an embryo. It’s a key player in allowing the body’s cells to divide without going haywire and forming a tumour. It regulates the body’s production of lipids, or fats, which can affect aging. Image credit: Pixabay (Free Pixabay license) Essentially,...
