The authors of this open access papers discuss the prominent role of cell signaling in the better known classes of intervention that have been shown to slow aging in worms, flies, and mice. The body is a network in which cells in one tissue influence the behavior of cells in other tissues via the signal molecules and vesicles that...
The enzyme choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine and could be a target molecule for pharmaceuticals. A Swedish research team has now determined the mechanism by which arylvinylpyridinium (AVP), a known class of ChAT inhibitors, functions. As they report in the journal Angewandte Chemie, ChAT manufactures the actual agent itself by attaching coenzyme A...
KYOTO UNIVERSITY IMAGE: ABNORMALITIES IN THE CHOLESTEROL TRANSPORT PROTEIN ABCA13 HAVE BEEN SHOWN TO LEAD TO SCHIZOPHRENIA IN A MOUSE MODEL. CREDIT: MINDY TAKAMIYA/KYOTO UNIVERSITY ICEMS Scientists have suspected mutations in a cellular cholesterol transport protein are associated with psychiatric disorders, but have found it difficult to prove this and to pinpoint how it happens....
IMMANUEL KANT BALTIC FEDERAL UNIVERSITY N-Aryl-C-nitroazoles are an important class of heterocyclic compounds. They are used as pesticides and fungicides. However, these substances could be toxic to humans and cause mutations. As they are not frequently used, there is little data about them in the medicinal chemistry literature. However, it has been suggested recently that...
by University of Pennsylvania Credit: CC0 Public Domain To effectively combat an infection, the body first has to sense it’s been invaded, then the affected tissue must send out signals to corral resources to fight the intruder. Knowing more about these early stages of pathogen recognition and response may provide scientists with crucial clues when it...
Lower stress, depression recalled after using drug, study finds OHIO STATE UNIVERSITY COLUMBUS, Ohio – A single positive experience on a psychedelic drug may help reduce stress, depression and anxiety symptoms in Black, Indigenous and people of color whose encounters with racism have had lasting harm, a new study suggests. The participants in the retrospective...
by Technical University Munich Thanks to artificial intelligence, the AIMOS software is able to recognize bones and organs on three-dimensional grayscale images and segments them, which makes the subsequent evaluation considerably easier. Credit: Astrid Eckert / TUM Imaging techniques enable a detailed look inside an organism. But interpreting the data is time-consuming and requires a great...
MEMORIAL SLOAN KETTERING CANCER CENTER Cancer cells are known for spreading genetic chaos. As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether. This is called chromosomal instability, and scientists at Memorial Sloan Kettering have learned that it is associated with cancer’s aggressiveness. The more unstable chromosomes are,...
Hugo J. Spiers Approaching the edge of a towering cliff is an unnerving experience. Watching another person do so can be equally unsettling. Our brain’s capacity to process these boundaries is important — not only for avoiding such dangers, but also for navigation in general, because borders that divide spaces can help to locate resources....
BRIGHAM AND WOMEN’S HOSPITAL Diabetes is a known risk factor for morbidity and mortality related to COVID-19. In diabetes patients, rare but severe complications, like the potentially lethal condition diabetic ketoacidosis (DKA), can arise when illness or certain conditions prevent cells from receiving enough glucose to fuel their functioning. An uptick in a particular type...
