Month: <span>January 2021</span>

Home / 2021 / January
Nasal spray delivers antipsychotic drugs straight to the brain, cutting required dose by up to 75 per cent and reducing adverse side effects
Post

Nasal spray delivers antipsychotic drugs straight to the brain, cutting required dose by up to 75 per cent and reducing adverse side effects

A team of neuroscientists and engineers at McMaster University has created a nasal spray to deliver antipsychotic medication directly to the brain instead of having it pass through the body. Image credit: Pixabay (Free Pixabay license) The leap in efficiency means patients with schizophrenia, bipolar disorder and other conditions could see their doses of powerful...

Motion sensitivity research could benefit people with inner ear condition
Post

Motion sensitivity research could benefit people with inner ear condition

Research into motion sensitivity could lead to improved rehabilitation programmes and an improvement in building designs for people with a rare inner ear condition that affects their balance. Dr Jessica Tyrrell at the University of Exeter’s Medical School will use the VSimulators research facility at Exeter Science Park to explore the response to different types and degrees of floor...

Reviving exhausted T cells gets them back in the fight against cancer
Post

Reviving exhausted T cells gets them back in the fight against cancer

By Michael Irving January 21, 2021 Researchers have found a mechanism by which T cells become “exhausted” fighting cancer – and potentially uncovered a way around it for four/Deposit photos VIEW 1 IMAGES One of the most promising emerging cancer therapies is CAR T cell immunotherapy, where a patient’s own immune cells are supercharged to fight...

Post

Pancreatic β cell-derived exosomal miR-29 family enhances hepatic glucose output

NANJING UNIVERSITY SCHOOL OF LIFE SCIENCES In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang’s group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig’s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs)....

Potential combined drug therapy for lung cancer
Post

Potential combined drug therapy for lung cancer

KANAZAWA UNIVERSITY IMAGE: GRAPHICAL SCHEMA SHOWING THE MECHANISM FOR OVERCOMING INTRINSIC RESISTANCE TO ALK-TKIS OWING TOTP53 MUTATIONS CREDIT: KANAZAWA UNIVERSITY Most lung cancers are of a type called non-small-cell lung carcinoma (NSCLC). This type of cancer is relatively insensitive to chemotherapy, so NSCLC therapies are usually based on drug treatment. Alectinib is a drug commonly...

For rising number of people, obesity is a literal headache
Post

For rising number of people, obesity is a literal headache

by Denise Mann  As worldwide obesity rates continue to soar, new research shows that growing numbers of people are developing a potentially blinding type of weight-linked headache that was once considered rare. Though the study was conducted in Wales, one U.S. expert said the same surge in these headaches is likely happening in this country and elsewhere,...

Researchers identify novel target that could improve the safety of CAR T cell therapy for pancreatic cancer
Post

Researchers identify novel target that could improve the safety of CAR T cell therapy for pancreatic cancer

by  Queen Mary, University of London A pancreatic islet from a mouse in a typical position, close to a blood vessel; insulin in red, nuclei in blue. Credit: Generated in the Solimena lab, Paul Langerhans Institute Dresden Researchers from Queen Mary University of London, have identified a protein that may represent a novel therapeutic target for the...

Up to a fifth of adults have mental health problems in midlife
Post

Up to a fifth of adults have mental health problems in midlife

by  University College London Credit: Pixabay/CC0 Public Domain Baby boomers and Generation X are at the greatest risk of mental ill-health in middle age, finds new UCL research. The study, published today in Psychological Medicine, reveals that 20% of those born in 1970—part of Generation X—19% of baby boomers born in 1946, and 15% of baby boomers born...

A new study shows the relationship between surgery and Alzheimer’s disease
Post

A new study shows the relationship between surgery and Alzheimer’s disease

IOS PRESS IMAGE: UNIDAD DE DETERIORO COGNITIVO CREDIT: VALDECILLA Amsterdam, January 21, 2021 – A new study published in the Journal of Alzheimer’s Disease carried out by researchers at the Marqués de Valdecilla-IDIVAL University Hospital, in collaboration with researchers at the University of Bonn Medical Center, proposes that major surgery is a promoter or accelerator of Alzheimer’s disease (AD). The...

Study defines small-cell lung cancer subtypes and distinct therapeutic vulnerabilities for each type
Post

Study defines small-cell lung cancer subtypes and distinct therapeutic vulnerabilities for each type

by  University of Texas M. D. Anderson Cancer Center Researchers from The University of Texas MD Anderson Cancer Center have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study published today in Cancer Cell. SCLC is...