by Massachusetts Institute of Technology Geomic created plots of the data that mapped differences pertaining to 4,300 genes along dimensions such as mouse age, the extent of Huntington’s-causing mutation, and cell type (certain neurons and astrocytes in a region of the brain called the striatum are especially vulnerable in Huntington’s). The plots took the form of...
by University of Barcelona A montage of three images of single striatal neurons transfected with a disease-associated version of huntingtin, the protein that causes Huntington’s disease. Nuclei of untransfected neurons are seen in the background (blue). The neuron in the center (yellow) contains an abnormal intracellular accumulation of huntingtin called an inclusion body (orange). Credit: Wikipedia/...
by Uppsala University Propranolol treatment contributes to reduced number and size of cerebral cavernous malformations. Panel A shows a brain section of vehicle treated mouse. The lesions are outlined in green. Credit: Joppe Oldenburg Propranolol, a drug that is efficacious against infantile haemangiomas (“strawberry naevi,” resembling birthmarks), can also be used to treat cerebral cavernous malformations,...
by Northwestern University Credit: CC0 Public Domain Northwestern University scientists have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS (amyotrophic lateral sclerosis), a swift and fatal neurodegenerative disease that paralyzes its victims. In addition to ALS, upper motor neuron degeneration also results in...
by Jake Ellison, University of Washington In a new study, researchers found that effective therapy for insomnia for people over 60 who also have joint pain can be delivered in a few sessions over the phone. Credit: Joshua Hoehne/Unsplash Insomnia—trouble falling asleep, staying asleep or waking up too early—is a common condition in older adults. Sleeplessness can be...
by Lila Reynolds, Northwestern University Credit: CC0 Public Domain Imagine if surgeons could transplant healthy neurons into patients living with neurodegenerative diseases or brain and spinal cord injuries. And imagine if they could “grow” these neurons in the laboratory from a patient’s own cells using a synthetic, highly bioactive material that is suitable for 3-D printing....
by University of California – San Diego Credit: CC0 Public Domain In a new study out of University of California San Diego School of Medicine, researchers have identified a universal strain of bacteria derived from healthy human skin that can treat the most common type of eczema, also known as atopic dermatitis. In the paper published Feb. 22,...
ELSEVIER IMAGE: : RUNX1 INHIBITION COMBINED WITH ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR (ANTI-VEGF) THERAPY ACHIEVES BETTER CONTROL OF EXPERIMENTAL CHOROIDAL NEOVASCULARIZATION ACTIVITY COMPARED TO MONOTHERAPY. CREDIT: THE AMERICAN JOURNAL OF PATHOLOGY Philadelphia, February 22, 2021 – Runt-related transcription factor 1 (RUNX1) has been linked to retinal neovascularization and the development of abnormal blood vessels, which result...
YALE UNIVERSITY Intravenous injection of bone marrow derived stem cells (MSCs) in patients with spinal cord injuries led to significant improvement in motor functions, researchers from Yale University and Japan report Feb. 18 in the Journal of Clinical Neurology and Neurosurgery. For more than half of the patients, substantial improvements in key functions — such as ability to...
UNIVERSITY OF MICHIGAN When you slip into sleep, it’s easy to imagine that your brain shuts down, but University of Michigan research suggests that groups of neurons activated during prior learning keep humming, tattooing memories into your brain. U-M researchers have been studying how memories associated with a specific sensory event are formed and stored in mice. In a study conducted...
