by Will Doss, Northwestern University Fig. 1 EZH2 increases FOXA1 protein stability through physical interaction. (A and B) PCa cells were infected with control (shCtrl) or two independent shEZH2 lentiviruses (shEZH2-C and shEZH2-3′) for 72 hours and subjected to WB. (C) LNCaP cells were infected with the indicated EZH2 lentivirus for 96 hours and analyzed by...
UNIVERSITY OF PENNSYLVANIA IMAGE: A GENETIC CONDITION KNOWN AS 22Q.11.2 DELETION SYNDROME IS ASSOCIATED WITH AN INCREASED RISK OF SCHIZOPHRENIA. A PENN VET-LED TEAM FOUND THAT A LEAKY BLOOD-BRAIN BARRIER, ALLOWING INAPPROPRIATE IMMUNE INVOLVEMENT CREDIT: COURTESY OF JORGE IVÁN ALVAREZ Like a stern bodyguard for the central nervous sytem, the blood-brain barrier keeps out anything...
COLLEGE OF ENGINEERING, CARNEGIE MELLON UNIVERSITY IMAGE: UNSUPERVISED IDENTIFICATION OF HIGH-FREQUENCY OSCILLATIONS CO-OCCURRING WITH EPILEPTIFORM SPIKES CREDIT: COLLEGE OF ENGINEERING, CARNEGIE MELLON UNIVERSITY Professor Bin He’s team at Carnegie Mellon University, in collaboration with the Mayo Clinic, has discovered that fast oscillations in scalp-recorded electroencephalography can pinpoint brain tissues responsible for epileptic seizures. The collaborative...
by University of South Florida Tau pathology resembling that seen in Alzheimer’s disease brains. Credit: Laura Blair’s laboratory, USF Health/University of South Florida Chaperone protein imbalance can play a significant role in initiating toxic accumulation of tau in the aging brain—an early step in the development of Alzheimer’s disease and related neurodegenerative disorders known as tauopathies,...
by University of Minnesota Credit: CC0 Public Domain Published in the Advanced Functional Materials, University of Minnesota researcher Hongbo Pang led a cross-institutional study on improving the efficacy of nucleotide-based drugs against prostate cancer and bone metastasis. In this study, Pang and his research team looked at whether liposomes, when integrated with the iRGD peptide, will help concentrate antisense...
Credit: CC0 Public Domain Sleeping six hours or less per night in your 50s and 60s is associated with an increased risk of dementia, according to a new study of nearly 8,000 British adults followed for more than 25 years. Scientists said that while the research, which was based on data from a long-running survey, could...
by Champalimaud Centre for the Unknown Sexual receptivity and rejection may be orchestrated by the same brain regionCertain neurons in the brains of female mice change their structure across the reproductive cycle, gaining higher complexity during the receptive phase. Credit: Champalimaud Centre for the Unknown – Lima Lab (data); Diogo Matias (design). In many species,...
The decline of the immune system is of great importance in aging. Vulnerability to infection, a decreased surveillance of senescent cells and cancerous cells, and growing chronic inflammation all take their toll. A sizable fraction of this problem stems from the diminished supply of new T cells of the adaptive immune system. T cells begin life as thymocytes in...
Repurposed drug works by building cells’ skeleton and transportation network. A simple dietary supplement reduces behavioral symptoms in mice with a genetic mutation that causes schizophrenia. After additional experiments, including visualizing the fluorescently stained dancing edge of immature brain cells, researchers concluded that the supplement likely protects proteins that build neurons’ cellular skeletons. The supplement betaine was...
A team of scientists from Russia studied the role of double-stranded fragments of the maturing RNA and showed that the interaction between distant parts of the RNA can regulate gene expression. The research was published in Nature Communications. Image credit: Pixabay (Free Pixabay license) At school, we learn that DNA is double-stranded and RNA is...
