TOHOKU UNIVERSITY IMAGE: (1) Astrocyte lysis: extensive loss of astrocytes with fragmented and/or dust-like particles; (2) progenitor recruitment: loss of astrocytes except small nucleated cells with GFAP-positive fibre-forming foot processes; (3) protoplasmic gliosis: presence of star-shaped astrocytes with abundant GFAP-reactive cytoplasm; and (4) fibrous gliosis: lesions composed of densely packed mature astrocytes. CREDIT: TOHOKU UNIVERSITY...
UNIVERSITY OF YORK The results of the first clinical trial of a new vaccine for a neglected tropical disease have demonstrated that it is safe and induces immune responses in patients with the infection. There are currently no vaccines to prevent leishmaniasis which is spread by the bite of sand flies and existing drugs have...
PHYSIKALISCH-TECHNISCHE BUNDESANSTALT (PTB) IMAGE: FOR THE FIRST TIME, RESEARCHERS WERE ABLE TO DEMONSTRATE THAT NONINVASIVELY MEASURED FAST BRAIN OSCILLATIONS SHOW SIGNIFICANT VARIABILITY FROM STIMULUS TO STIMULUS (ROWS), BOTH IN TERMS OF THE TIMING OF SUCCESSIVE ACTION POTENTIALS (SHIFT IN BLUE/RED VERTICAL BANDS) AND IN TERMS OF THEIR STRENGTH (COLOR INTENSITY). CREDIT: CHARITÉ | GUNNAR WATERSTRAAT...
CEDARS-SINAI MEDICAL CENTER IMAGE: LEIGH ELLIS, PHD CREDIT: CEDARS-SINAI LOS ANGELES (April 15, 2021) — Researchers have discovered a new way to transform the tissues surrounding prostate tumors to help the body’s immune cells fight the cancer. The discovery, made in human and mouse cells and in laboratory mice, could lead to improvements in immunotherapy treatments for...
by Karolinska Institutet An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia The causes of the serious muscle disease ALS still remain unknown. Now, researchers at Karolinska Institutet and KTH Royal Institute of Technology, among others, have...
by Salk Institute A dense-core amyloid-beta plaque (red) surrounded by microglia that lack TAM receptors (white) in the brain of a mouse with Alzheimer’s disease. Credit: Salk Institute One of the characteristic hallmarks of Alzheimer’s disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but...
by Doug Dollemore, University of Utah Health Sciences A new University of Utah Health study suggests that Staufen1, a protein that accumulates in the brains of.certain patients, is linked to several neurodegenerative disorders. Unsplash/CC0 Public Domain Neurological disorders are the number one cause of disability in the world, leading to seven million deaths each year. Yet...
by University of Zurich Fig. 1: Experimental task and neural conflict-induced upregulation responses (CI > II). Credit: Nature Communications (2021). DOI: 10.1038/s41467-021-22509-1 Researchers at the University of Zurich show that increased sensitivity in a specific region of the brain contributes to the development of anxiety and depression in response to real-life stress. Their study establishes an objective neurobiological measure for stress...
by Salk Institute Using fluorescent stains, researchers are able to visualize cells of different species origins in an early stage embryo. Credit: Weizhi Ji, Kunming University of Science and Technology The ability to grow the cells of one species within an organism of a different species offers scientists a powerful tool for research and medicine. It’s an approach that could...
by Elsevier Credit: CC0 Public Domain A new study shows that markers of fear recall differ between men and women, but in a hormone-dependent manner. Aberrant fear-memory processing in the brain is thought to underlie anxiety disorders, which affect hundreds of millions of people worldwide. The neurobiological mechanisms underlying these disorders remain poorly understood, but recent studies...
