NYU LANGONE HEALTH / NYU SCHOOL OF MEDICINE Early results show that a new combination drug therapy is safe and effective against advanced skin cancer in patients who were not able to have their tumors surgically removed. The drug combination is among the first, researchers say, to demonstrate the potential value of a live common cold virus,...
Month: <span>April 2021</span>
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Aluminum is intricately associated with the neuropathology of familial Alzheimer’s disease
IOS PRESS IMAGE: THE IMAGE SHOWS ALUMINUM (ORANGE) IN A NEURON IN A DONOR’S BRAIN TISSUE WITH FAMILIAL ALZHEIMER’S DISEASE. THE SAME NEURON REVEALED POSITIVE IMMUNOSTAINING (BROWN) FOR PHOSPHORYLATED TAU (PTAU). MERGING THESE IMAGES SHOWED THAT ALUMINIUM AND pTau ARE CO-LOCATE DIN THE SAME CELL. CREDIT: DR. MOLD Amsterdam, April 9, 2021 — This study builds upon...
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New biosealant can stabilize cartilage, promote healing after injury
UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE A new biosealant therapy may help to stabilize injuries that cause cartilage to break down, paving the way for a future fix or – even better – begin working right away with new cells to enhance healing, according to a new animal-based study by researchers at the Perelman School of Medicine...
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Researchers have found that they can indirectly retrieve and weaken traumatic memories
by Caitlin Clark, Texas A&M University Credit: CC0 Public Domain Scientists could be a step closer to finding a way to reduce the impact of traumatic memories, according to a Texas A&M University study published recently in the journal Nature Neuroscience. The report details a study by researchers from the Department of Psychological and Brain Sciences and the Institute...
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Toward a reliable oral treatment for sickle cell disease
by American Chemical Society This X-ray structure shows FTX-6058 bound to its protein target. Credit: Fulcrum Therapeutics For the millions of people worldwide who have sickle cell disease, there are only a few treatment options, which include risky bone marrow transplants, gene therapy or other treatments that address a subset of symptoms. Today, researchers will describe the discovery...
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Interleukin-33 involved in immunity to SARS-CoV-2
by Max Planck Society White blood cells play an important role in the defense against pathogens. Credit: MPI f. Developmental Biology/ Jürgen Berger Early in the pandemic, a team of immunologists from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and physicians from the University of Freiburg Medical Center joined forces to learn more...
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Genes and immune cells predict immunotherapy success in bladder cancer
by The Mount Sinai Hospital Credit: CC0 Public Domain Sets of genes associated with resistance to immunotherapy in patients with metastatic urothelial cancer of the bladder have been identified and validated by researchers at Mount Sinai. In a study published in Clinical Cancer Research, the team uncovered gene signatures representing adaptive immunity and pro-tumorigenic inflammation that were responsible for sensitivity or...
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Mutations to Dyrk1a gene lead to brain undergrowth; an existing drug rescues the condition in newborn mice
SCRIPPS RESEARCH INSTITUTE IMAGE: A SIDE-BY-SIDE LOOK AT THE BRAINS OF A NORMAL NEWBORN MOUSE AND ONE LACKING THE AUTISM AND INTELLECTUAL DISABILITY RISK GENE DYRK1A. CREDIT: DAMON PAGE LAB, SCRIPPS RESEARCH JUPITER, FL — Damage to the autism-associated gene Dyrk1a, sets off a cascade of problems in developing mouse brains, resulting in abnormal growth-factor signaling, undergrowth of...
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Screening for skin disease on your laptop
UNIVERSITY OF HOUSTON IMAGE: METIN AKAY, JOHN S. DUNN ENDOWED CHAIR PROFESSOR OF BIOMEDICAL ENGINEERING AT UNIVERSITY OF HOUSTON, HAS DEVELOPED A NEW DEEP NEURAL NETWORK THAT PROVIDES EARLY DIAGNOSIS OF SYSTEMIC SCLEROSIS, A RARE AUTOIMMUNE DISEASE MARKED BY HARDENED OR FIBROUS SKIN AND INTERNAL ORGANS. CREDIT: UNIVERSITY OF HOUSTON The founding chair of the...
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Blocking a protein could help overcome cancer resistance to PARP inhibitors
by The Francis Crick Institute Micrograph showing a lymph node invaded by ductal breast carcinoma, with extension of the tumour beyond the lymph node. Credit: Nephron/Wikipedia Researchers at the Francis Crick Institute have found that blocking a specific protein could increase tumor sensitivity to treatment with PARP inhibitors. Their work published in Science , suggests combining treatments could lead...