Hydrogels are often used as drug delivery systems, but to be effective carriers for anti-cancer drugs, they need to be responsive to varied stimuli in the tumor microenvironment. Now, scientists from Japan have developed novel hydrogels to effectively deliver drugs to tumor sites in response to temperature and pH changes in the tumor microenvironment. These...
ALPHAMED PRESS IMAGE: EXAMPLES OF COMPLETE CLOSURE (100%). CREDIT: ALPHAMED PRESS Durham, NC – According to the results of a phase 1 clinical trial just published in STEM CELLS Translational Medicine, a new stem cell therapy shows promise of making diabetes-related amputations a thing of the past. The trial involved injecting diabetes patients suffering from non-healing...
BOSTON UNIVERSITY SCHOOL OF MEDICINE (Boston)–Diagnosing Chronic Traumatic Encephalopathy (CTE) during life is crucial for developing therapies and for determining how common the disease is among individuals exposed to repetitive head impacts from contact sports, military service and physical violence. While the ability to diagnose CTE prior to death has remained elusive, researchers from Boston University School...
NAGOYA INSTITUTE OF TECHNOLOGY IMAGE: RESEARCHERS MADE EACH PARTICIPANT STAND ON A BALANCE BOARD, ATTACHED FASTENERS TO THEIR BODY AND LEGS AND THEN GENERATED VIBRATION SIGNALS ON THEIR PC WHICH THEY AMPLIFIED AND APPLIED TO THE VIBRATORS TO INDUCE STIMULATION. CREDIT: IMAGE COURTESY: YOSHIFUMI MORITA FROM NAGOYA INSTITUTE OF TECHNOLOGY Ever since the early humans...
UNIVERSITY OF TSUKUBA Tsukuba, Japan – Dermatomyositis is an idiopathic inflammatory myopathy that has been regarded as an autoimmunity-based disorder, although its pathogenesis remains unclear. In this study, researchers from the University of Tsukuba used a mouse model to identify a mechanism by which dermatomyositis may develop in humans. The animal model and findings can be used...
by Lancet Credit: CC0 Public Domain One in three COVID-19 survivors received a neurological or psychiatric diagnosis within six months of infection with the SARS-CoV-2 virus, an observational study of more than 230,000 patient health records published in The Lancet Psychiatry journal estimates. The study looked at 14 neurological and mental health disorders. Professor Paul Harrison, lead author...
by University of North Carolina Health Care Right, miRNA29-deficient mice showing a marked increase in the important enzyme DNMT3A (bright light blue). Credit: Deshmukh Lab, UNC School of Medicine A team led by scientists at the UNC School of Medicine identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29...
by American Chemical Society Immunofluorescence images show that some α-synuclein and Pmel17 are in the same locations in human melanoma cells. Credit: Dexter Dean, Ph.D. On the surface, Parkinson’s disease—a neurodegenerative disorder—and melanoma—a type of skin cancer—do not appear to have much in common. However, for nearly 50 years, doctors have recognized that Parkinson’s disease patients...
by Gillian Rutherford, University of Alberta Pharmacy researcher John Ussher led new research identifying a protein that could be key to developing treatments to prevent a type of heart failure that is common but often hidden in people with Type 2 diabetes. Credit: Julia Brown Photography A University of Alberta laboratory has uncovered a new approach to preventing...
by Peter MacCallum Cancer Centre Credit: CC0 Public Domain For patients with some hard-to-treat blood cancers, a simple “off-the-shelf” immunotherapy is achieving promising results. A clinical trial of the developmental drug Glofitamab has shown it can produce a durable “complete response”—meaning the cancer became undetectable—in patients with relapsed or treatment resistant B-cell lymphomas. One option for these...
