by University of Dundee Fig. 1: 3D crystal structure of human OGT with mapped variants. Credit: European Journal of Human Genetics (2020). DOI: 10.1038/s41431-020-0589-9 University of Dundee researchers have discovered a new neurodevelopmental disease caused by genetic mutations and helped explain why patients with these mutations suffer this condition. Around 1% of the global population are affected by intellectual disability, a condition characterized...
by University of Dundee The four different test conditions: (A) barefoot (B) shoes (C) tape with bare feet (D) tape with shoes. Credit: BMJ Open Sport & Exercise Medicine (2020). DOI: 10.1136/bmjsem-2019-000604 It has been adopted by the likes of Cristiano Ronaldo, Tiger Woods and Andy Murray as a colorful way to help them play through pain, but research from...
by Linda Koffmar, Uppsala University Credit: Circulation Research (2021). DOI: 10.1161/CIRCRESAHA.120.318380 Cardiovascular disease, the most common cause of death, is the result of oxygen deprivation as blood perfusion to affected tissue is prevented. To halt the development of the disease and to promote healing, re-establishment of blood flow is crucial. Researchers at Uppsala University have now discovered that one of the...
by Will Doss, Northwestern University Credit: CC0 Public Domain Boosting mitochondrial function in a subpopulation of T cells could make cancer immunotherapy more effective, according to a recent study published in the Proceedings of the National Academy of Sciences (PNAS). Those cells, known as CD1d-restricted natural killer T (NKT) cells, are much more reliant on mitochondrial metabolism during development...
by Monash University Credit: CC0 Public Domain Hemorrhoids, also called piles, affect a large portion of the population, for reasons that have mostly remained unknown. Now an international study which investigated the DNA of nearly 1 million people has identified some likely causes. Found at the very end of the digestive tract, hemorrhoids are blood filled...
by Lund University Credit: Unsplash/CC0 Public Domain People with type 2 diabetes tend to have poorer muscle function than others. Now a research team at Lund University in Sweden has discovered that in type 2 diabetes, a specific gene is of great importance for the ability of muscle stem cells to create new mature muscle cells. The findings...
by Taylor Kubota, Stanford University Credit: Stanford University Being unable to walk quickly can be frustrating and problematic, but it is a common issue, especially as people age. Noting the pervasiveness of slower-than-desired walking, engineers at Stanford University have tested how well a prototype exoskeleton system they have developed—which attaches around the shin and into a...
by Delthia Ricks , Medical Xpress Credit: CC0 Public Domain Canadian immunologists have identified a mechanism that promotes the activation of T cell receptors by altering how one of its components interacts with the cell membrane. The finding sheds new light on the function of T cell receptors, illuminating the role of specific proteins in...
On 11 April 2021, infectious disease physician and retired U.S. Army colonel Matt Hepburn gave an interview on the American television news program 60 Minutes, where he described a new technology developed by the researchers at the U.S. Defense Advanced Research Projects Agency (DARPA) and the biotech company Profusa. Specifically, researchers developed a hydrogel sensor...
Published: August 09, 2020 Public Summary Immunotherapy has revolutionized the therapeutic landscape of gastrointestinal cancer, based on a series of clinical trials conducted in recent years. The next level of predictive biomarker of the response to immune checkpoint inhibitors (ICIs) should address the integration of current multi-omics biomarkers with an interdisciplinary approach. The emerging combination...
