The protein made by the ASH1L gene plays a key role in the development of acute leukemia, along with other diseases. The ASH1L protein, however, has been challenging to target therapeutically. Now a team of researchers led by Jolanta Grembecka, Ph.D., and Tomasz Cierpicki, Ph.D., from the University of Michigan has developed first-in-class small molecules to inhibit ASH1L’s SET domain — preventing critical...
AMERICAN INSTITUTE OF PHYSICS IMAGE: SCHEMATIC AND PHOTOGRAPH OF COVID-19 SENSOR STRIP AND THE PRINTED CIRCUIT BOARD FABRICATED TO PRODUCE A DIGITAL SENSOR OUTPUT. CREDIT: MINGHAN XIAN, HAO LUO, XINYI XIA, CHAKER FARES, PATRICK H. CAREY IV, CHAN-WEN CHIU, FAN REN, SIANG-SIN SHAN, YU-TE LIAO, SHU-MIN HSU, JOSEPHINE F. ESQUIVEL-UPSHAW, CHIN-WEI CHANG, JENSHAN LIN, STEVEN…...
AMERICAN INSTITUTE OF PHYSICS CREDIT: VLADISLAV YAKOVLEV/TEXAS A&M UNIVERSITY CAPTION Schematic illustration of photodynamic inactivation of various viruses. WASHINGTON, May 18, 2021 — The COVID-19 pandemic has reinforced the pressing need to mitigate a fast-developing virus as well as antibiotic-resistant bacteria that are growing at alarming rates worldwide. Photodynamic therapy (PDT), or using light to...
NARA INSTITUTE OF SCIENCE AND TECHNOLOGY IMAGE: Shootin1a Is Required for Spine Structural Plasticity. Fluorescence time-lapse images of dendritic spines (A) and time course of their volume changes (B) of hippocampal neurons in slice culture. Spines were stimulated by local application of neurotransmitter glutamate for 30 s (red asterisks). 30-sec stimulation of control spines induced...
CITY OF HOPE An international team of scientists from the Menzies Health Institute Queensland (MHIQ) at Griffith University and from City of Hope, a research and treatment center for cancer, diabetes and other life-threatening diseases in the U.S., have developed an experimental direct-acting antiviral therapy to treat COVID-19. Traditional antivirals reduce symptoms and help people recover earlier....
ELIFE Alzheimer’s disease shares some key similarities with healthy aging, according to a new mathematical model described today in eLife. The model provides unique insights into the multiscale biological alterations in the elderly and neurodegenerative brain, with important implications for identifying future treatment targets for Alzheimer’s disease. Researchers developed their mathematical model using a range of biological...
UNIVERSITY OF KONSTANZ A new cancer vaccine could boost the positive effects of existing immunotherapy drugs, improving the success rate of treatments from 20% to 75% of cases, according to a new study by immunologists from the University of Konstanz. The vaccine, which incorporates a new immunostimulant that is safe for use in humans, was...
By Ben CoxworthMay 17, 2021 One of the “smart” bandages, which could be manufactured in a variety of shapes and sizesNegar Rahmani. While it’s important to check wounds for infections, removing the dressing in order to do so can be disruptive to the healing process. A new smart bandage could help, by “glowing” in a certain...
By Rich Haridy May 17, 2021 An asthma vaccine was found to be effective in preclinical mouse models and researchers are now looking to move to human safety trialsalliesinteract/Depositphotos A new article in the journal Nature Communications is reporting successful results from preclinical tests for a unique asthma vaccine. The results indicate the vaccine generates antibodies against...
by University of Zurich A piece of the tumor was made completely transparent and scanned in 3D with a special microscope. The components labeled with fluorescent colors were rendered in a rotatable 3D representation on the computer (red: blood vessels, turquoise: tumor cells, yellow: therapeutic antibody). Credit: Plückthun Lab A new technology developed by UZH researchers enables the...
