by University of Southampton Image of the 3D ’tissue like’ culture system, developed by Dr Liku Tezera. Credit: Faculty of Medicine New research using human lung samples and three-dimensional bioengineering techniques to replicate the lung environment has revealed the important role of a subset of immune cells in the lung in fighting tuberculosis (TB). The cells, called T...
Zapping Nerves with Ultrasound Lowers Drug-Resistant Blood Pressure
Brief pulses of ultrasound delivered to nerves near the kidney produced a clinically meaningful drop in blood pressure in people whose hypertension did not respond to a triple cocktail of medications, reports a new study led by researchers at Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian.Ajay J. Kirtane In a clinical trial of the...
New research optimizes body’s own immune system to fight cancer
A groundbreaking study led by engineering and medical researchers at the University of Minnesota Twin Cities shows how engineered immune cells used in new cancer therapies can overcome physical barriers to allow a patient’s own immune system to fight tumors. The research could improve cancer therapies in the future for millions of people worldwide. The research is published...
Multiple sclerosis: how to halt its progression?
Researchers at the CRCHUM led by neurosciences professor Nathalie Arbour are tracking the molecules responsible for this autoimmune disease affecting more than 90,000 Canadians. Did you know that more than 90,000 Canadians are living with multiple sclerosis (MS)? That’s more than the number of people with HIV in the country. And yet it’s not widely talked about....
Gut hormone triggers craving for more proteins
THE KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KAIST) IMAGE: OVERVIEW OF THE MICROBIOME-GUT-BRAIN AXIS. CNMA IS UPREGULATED BY ATF4 AND MITF (AND POSSIBLY OTHER UNKNOWN FACTORS) DURING THE DEPRIVATION OF ESSENTIAL AMINO ACIDS, AND THIS ACTS ON CNMAR-EXPRESSING NEURONS TO STIMULATE THE COMPENSATORY APPETITE FOR ESSENTIAL AMINO ACIDS. CREDIT: PROFESSOR GREG SEONG-BAE SUH, KAIST...
Sotagliflozin shows benefit for difficult-to-treat form of heart failure
AMERICAN COLLEGE OF CARDIOLOGY Patients with both diabetes and heart failure who were treated with sotagliflozin, a novel investigational drug for diabetes, for a median of nine to 16 months experienced reductions of 22% to 43% in the risk of death or worsening heart failure compared with similar patients who were treated with a placebo....
Comprehensive Mount Sinai study shows direct evidence that COVID-19 can infect cells in eye
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE Paper Title: SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium Authors: Timothy Blenkinsop, PhD, Assistant Professor, Cell, Developmental & Regenerative Biology, and Benjamin tenOever, PhD, Professor, Microbiology, Icahn School of Medicine at Mount Sinai, New York, and other coauthors. Bottom Line: SARS-CoV-2, the causative...
An asthma vaccine effective in mice
INSTITUT PASTEUR Inserm teams led by Laurent Reber (Infinity, Toulouse) and Pierre Bruhns (Humoral Immunity, Institut Pasteur, Paris) and French company NEOVACS have developed a vaccine that could induce long-term protection against allergic asthma, reducing the severity of its symptoms and thus significantly improving patient quality of life. Their research in animals has been published in the...
First immune stimulating long noncoding RNA involved in body’s response to cancer
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN A long noncoding RNA whose function was previously unknown turns out to play an important role in promoting the body’s immune response against cancer and holds promise for enhancing the efficacy of anti-cancer immunotherapy. That’s according to new findings reported in Nature Cell Biology by researchers at the University of Michigan Rogel Cancer...
Novel gene identified as genetic cause of portal hypertension
by Julie Parry, Yale University Credit: CC0 Public Domain The liver serves many critical functions within the human body, including the production of critical proteins, and the removal of waste and toxins. But when damage occurs to the largest organ in the body, many people do not experience symptoms until serious damage has occurred. When the...