by Zhang Nannan, Chinese Academy of Sciences Fig.1. Schematic summary of the exacerbated α-syn neuropathology in heterozygous familial PD. Credit: SIOC Amyloid deposition of α-synuclein (α-syn) is a hallmark of Parkinson’s disease (PD). α-Syn fibrillation and cell-to-cell transmission in the brain play an essential role in disease progression. To date, eight single-point mutations of SNCA have...
by European Association for the Study of Obesity New research presented at this year’s European Congress on Obesity (held online, 10-13 May) shows that treatment with the drug semaglutide reduces body weight in adults with overweight or obesity, regardless of their baseline characteristics. However, the study showed that female participants had slightly better results than males and also that...
by Johns Hopkins University School of Medicine Credit: CC0 Public Domain Chronic itch—known clinically as chronic pruritus—is characterized as an unrelenting and sometimes even debilitating sensation to itch, and often lowers the quality of life for those who suffer with it. Treating the condition has been difficult because there are few Food and Drug Administration-approved therapies....
by The Mount Sinai Hospital Credit: Pixabay/CC0 Public Domain Artificial food colorants can cause disease when the immune system has become dysregulated, Icahn School of Medicine at Mount Sinai researchers report. The study, published in Cell Metabolism in May, was the first to show this phenomenon. The study, conducted in mice, found that the mice developed colitis when they consumed...
In a new study, researchers demonstrated that COVID-19 can lead to long-term erectile dysfunction, yet another sign that victims of the deadly virus often suffer from lasting symptoms even long after they recovered from the viral infection itself. The study, published in the World Journal of Men’s Health last week, found that COVID-19 can result in endothelial dysfunction,...
BY TIM CHILDERSNOV 19, 2020 A landmark study shows the reversal of biological aging in humans. The researchers used oxygen therapy in a pressurized chamber to reverse aging in two key biological clocks. The study showed lengthening in the telomeres of chromosomes and a decrease in cells known to cause aging. The cure for aging has long been the Holy Grail...
Simultaneous measurement of neural rhythms and spikes across five brain areas reveals how propofol induces unconsciousness. In a uniquely deep and detailed look at how the commonly used anesthetic propofol causes unconsciousness, a collaboration of labs at the Picower Institute for Learning and Memory at MIT shows that as the drug takes hold in the...
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO IMAGE: A REVIEW ARTICLE SHOWS THAT ALTERATIONS IN THE DEFENSE CELL METABOLISM MAY EXPLAIN WHY MANY PATIENTS WHO SURVIVE SEPSIS DIE WITHIN A YEAR OR SUFFER FROM LONG-TERM COMPLICATIONS. CREDIT: TALITA SOUZA-SIQUEIRA An article published in Frontiers in Immunology suggests that sepsis can cause alterations in the functioning of...
UNIVERSITY OF CHICAGO IMAGE: A team of chemists with the University of Chicago announced a new technique that allows scientists to easily cut nitrogen atoms from molecules–which can make the process of finding new molecules for medicines or other uses easier and faster. Above: Study coauthors Balu Dherange and Kathleen Berger demonstrate a drawing of...
OREGON HEALTH & SCIENCE UNIVERSITY Scientists have for the first time revealed the structure surrounding important receptors in the brain’s hippocampus, the seat of memory and learning. The study, carried out at Oregon Health & Science University, published today in the journal Nature. The new study focuses on the organization and function of glutamate receptors, a...
