PRILENIA Newly published papers further elucidate the mechanisms underlying pridopidine’s neuroprotective properties through activation of the Sigma-1 Receptor (S1R). Pridopidine enhances mitochondrial function and reduces mHTT-induced ER stress, which are impaired in HD, mediated by the S1R. Three new peer-reviewed publications highlight pridopidine’s therapeutic potential and provide data supporting the role of the S1R in...
Month: <span>May 2021</span>
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Press (re)play to remember – How the brain strengthens memories during sleep
UNIVERSITY OF BIRMINGHAM While we sleep, the brain produces particular activation patterns. When two of these patterns – slow oscillations and sleep spindles – gear into each other, previous experiences are reactivated. The stronger the reactivation, the clearer will be our recall of past events, a new study reveals. Scientists have long known that slow...
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Data from smartwatches can help predict clinical blood test results
DUKE UNIVERSITY IMAGE: THE IMAGE SHOWS THE HEART RATE MONITOR READING ON A STANDARD SMARTWATCH. CREDIT: MICHAELA KANE, DUKE UNIVERSITY DURHAM, N.C. — Smartwatches and other wearable devices may be used to sense illness, dehydration and even changes to the red blood cell count, according to biomedical engineers and genomics researchers at Duke University and the Stanford...
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Superoxide produced in the cochlea of inner ears causes acquired hearing loss
KOBE UNIVERSITY IMAGE: The top image is a cross-section of the organ of Corti from a 12-month-old mouse (homozygous Nox3-Cre+/+;tdTomato) and the bottom image is an illustration of this. Red fluorescent proteins (tdTomato), in other words Nox3, are expressed in the outer and inner hair cells, as well as in various types of supporting cells...
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Vitamin B6 deficiency enhances the noradrenergic system, leading to behavioral deficits
TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE IMAGE: (A) VB6(-) mice showed hyperactivate noradrenergic (NAergic) signaling, resulting in behavioral deficits comparable to schizophrenia. (B) These are ameliorated by VB6 supplementation into the brain or treatment with the 2A adrenoreceptor agonist guanfacine (GFC), which suppresses NA release. CREDIT: TMIMS Schizophrenia is a heterogeneous psychiatric disorder characterized by...
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Low blood flow in the brain may be an early sign of Parkinson’s disease
AARHUS UNIVERSITY Patients who suffer from REM sleep behaviour disorder have altered blood flow in the brain, which can lead to a lack of oxygen in the brain tissue. In the long term, this may cause symptoms of Parkinson’s disease. This is shown by research from Aarhus University and Aarhus University Hospital. Do you sleep restlessly and...
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Wearable devices show that physical activity may lower atrial fibrillation and stroke risk
MASSACHUSETTS GENERAL HOSPITAL BOSTON – Physical activity that conforms to medical and health association guidelines is associated with a lower risk of atrial fibrillation (Afib) and stroke, according to a study by researchers at Massachusetts General Hospital (MGH), who analyzed nearly 100,000 individuals equipped with wrist-worn accelerometers to measure their movement. The researchers’ findings suggest that data from...
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New AI technology protects privacy
TECHNICAL UNIVERSITY OF MUNICH (TUM) IMAGE: PD DR. RICKMER BRAREN (L.) UND PROF. DANIEL RUECKERT (R.) EXPLORING DIAGNOSTIC POSSIBILITIES USING ARTIFICIAL INTELLIGENCE FOR MEDICAL IMAGE DATA. CREDIT: ANDREAS HEDDERGOTT / TUM Digital medicine is opening up entirely new possibilities. For example, it can detect tumors at an early stage. But the effectiveness of new AI...
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Weight-loss treatment prevents accumulation of lipid linked to cardiac mortality
by Karolinska Institutet Credit: N. Akawi et al. J Am Coll Cardiol 2021 Researchers at the Karolinska Institutet, University of Oxford and University of Copenhagen have shown that elevated levels of lipids known as ceramides can be associated with a ten-fold higher risk of death from cardiovascular disease. Treatment with liraglutide could keep the ceramide levels in...
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Intermittent fasting in mice effective at promoting long term memory retention
by King’s College London Credit: Pixabay/CC0 Public Domain A new study from the Institute of Psychiatry, Psychology and Neuroscience (IoPPN) at King’s College London has established that Intermittent Fasting (IF) is an effective means of improving long term memory retention and generating new adult hippocampal neurons in mice, in what the researchers hope has the potential to slow...