Modern medicine relies on an extensive arsenal of drugs to combat deadly diseases such as pneumonia, tuberculosis, HIV-AIDS and malaria. Chemotherapy agents have prolonged lives for millions of cancer patients, and in some cases, cured the disease or turned it into a chronic condition. But getting those drugs into disease-ridden cells has remained a major...
Artificial intelligence system may improve diagnosis of complicated metastatic cancers
BRIGHAM AND WOMEN’S HOSPITAL In 1 to 2 percent of cancer cases, the primary site of tumor origin cannot be determined. Because many modern cancer therapeutics target primary tumors, the prognosis for a cancer of unknown primary (CUP) is poor, with a median overall survival of 2.7-to-16 months. In order to receive a more specific...
Total knee replacement may be more painful for vitamin-D deficient postmenopausal women
THE NORTH AMERICAN MENOPAUSE SOCIETY (NAMS) CLEVELAND, Ohio (May 5, 2021)–Vitamin D is a critical part of a healthy diet. Among other benefits, it has been shown to protect against bone disease and maintain soft tissue health. A new study suggests that it may also play a role in the degree of postoperative pain postmenopausal...
Prediabetes may not be as benign as once thought
AMERICAN COLLEGE OF CARDIOLOGY People with prediabetes were significantly more likely to suffer a heart attack, stroke or other major cardiovascular event when compared with those who had normal blood sugar levels, according to research being presented at the American College of Cardiology’s 70th Annual Scientific Session. Researchers said the findings should serve as a wake-up call for clinicians...
New MRI technique can detect early dysfunction of the blood-brain barrier with small vessel disease
UNIVERSITY OF KENTUCKY LEXINGTON, Ky. (May 5, 2021) – Collaborative research between the University of Kentucky (UK) and University of Southern California (USC) suggests that a noninvasive neuroimaging technique may index early-stage blood-brain barrier (BBB) dysfunction associated with small vessel disease (SVD). Cerebral SVD is the most common cause of vascular cognitive impairment, with a...
Examination of an Estonian patient helped discover a new form of muscular dystrophy
ESTONIAN RESEARCH COUNCIL IMAGE: PROFESSOR OF CLINICAL GENETICS OF THE UNIVERSITY OF TARTU KATRIN ÕUNAP. CREDIT: UNIVERSITY OF TARTU In about a quarter of patients with hereditary diseases, the cause of the disease remains unclear even after extensive genetic testing. One reason is that we still do not know enough about the function of many genes. Of...
Sex-specific genetics of autism
MEDICAL UNIVERSITY OF SOUTH CAROLINA IMAGE: CORONAL SECTION OF A MOUSE BRAIN, WITH SEVERAL MAJOR AXONAL TRACTS STAINED IN GREEN. IMAGE COURTESY OF DR. AHLEM ASSALI. CREDIT: DR. AHLEM ASSALI, MEDICAL UNIVERSITY OF SOUTH CAROLINA After reviewing a database of gene mutations in children with autism spectrum disorder (ASD), a team of Medical University of...
Microneedles are promising devices for painless drug delivery with minimal side effects
UNIVERSITY OF HELSINKI IMAGE: RESEARCHERS SUGGEST USING MICRONEEDLES FOR IMMUNOTHERAPY DUE TO THE HIGH ABUNDANCE OF IMMUNE CELLS UNDER THE SKIN. CREDIT: SANTOS LAB, UNIVERSITY OF HELSINKI A recent study from the University of Helsinki monitors the breakthrough progresses in the development of microneedles for immunotherapy and discusses the challenges regarding their production. Researchers suggest using microneedles...
Researchers successfully use 3-D ‘bioprinting’ to create nose cartilage
by Ross Neitz, University of Alberta Faculty of Medicine & Dentistry 3-D printed cartilage is shaped into a curve suitable for use in surgery to rebuild a nose. The technology could eventually replace the traditional method of taking cartilage from the patient’s rib, a procedure that comes with complications. Credit: University of Alberta A team of...
A trait of the rare few whose bodies naturally control HIV: ‘Trained’ immune cells
by Massachusetts General Hospital HIV (yellow) infecting a human immune cell. Credit: Seth Pincus, Elizabeth Fischer and Austin Athman, National Institute of Allergy and Infectious Diseases, National Institutes of Health Immunity often calls to mind the adaptive immune response, made up of antibodies and T cells that learn to fight specific pathogens after infection or vaccination....