EXPERIMENTAL BIOLOGY IMAGE: HAYDEN HESS, PHD CREDIT: HAYDEN HESS Rockville, Md. (April 27, 2021)–Exposure to extreme heat (95 degrees Fahrenheit and above) and humidity for eight hours raises the core body temperature and causes dehydration, resulting in an increased risk of acute kidney injury, according to a new study. The researchers, from the Indiana University School...
EXPERIMENTAL BIOLOGY Rockville, Md. (April 27, 2021)–New research to be presented this week virtually at the American Physiological Society’s (APS) annual meeting at Experimental Biology 2021 explores the positive and negative effects of lifespan-extending drugs on mitochondrial function and age-related osteoarthritis (OA). Decreased function of mitochondria–the energy centers of the cells–is a hallmark characteristic of aging. Maintaining...
Researchers here show that increased levels of cap-independent translation (CIT) of messenger RNA (mRNA) take place in a diverse set of interventions known to modestly slow aging in mice, suggesting it to be a common phenomenon in these shifts of metabolism towards a slower pace of aging. CIT is a process that in part drives the movement of mRNA, produced from genetic...
Researchers at Penn Medicine uncover more genetic mutations that predispose women to peripartum cardiomyopathy, with implications for the future of increased genetic testing. Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), a rare condition characterized by weakness of the heart muscle that begins sometime during...
As reported in Science Translational Medicine, researchers pinpointed a protein called melanocortin 3 receptor (or MC3R) as an avenue for accessing the brain circuitry that controls the body’s energy balance and food intake. The research offers preliminary evidence that manipulating the MC3R can either stimulate or suppress food intake. The MC3R sits on the surface of neurons,...
The discovery came from a series of experiments that began with amoebas—single-celled organisms that extend podlike appendages to move around. “Physician-scientists and fundamental biologists worked together to understand a problem at the root of a major human illness, and the problem, as often happens, relates to the core biology of cells,” says Doug Robinson, professor...
EXPERIMENTAL BIOLOGY CREDIT: AMERICAN PHYSIOLOGICAL SOCIETY Rockville, Md. (April 27, 2021)–People who self-report daytime sleepiness were found to have shorter telomeres regardless of whether they had obstructive sleep apnea, according to a new study from researchers at the Mayo Clinic in Rochester, Minnesota. The findings will be presented virtually at the American Physiological Society’s (APS) annual meeting...
EXPERIMENTAL BIOLOGY A new study found that non-pungent synthetic analog of capsaicin — the compound that makes chili peppers hot — made small cell lung cancer cells more responsive to treatment. Small cell lung cancer is a very aggressive form of cancer with a low survival rate. Cisplatin-based combination chemotherapy is typically the first-line treatment...
EXPERIMENTAL BIOLOGY IMAGE: A SCHEMATIC ILLUSTRATING HOW PEITC TREATMENT AFFECTED INDUCED NEPHROPATHY IN RATS BY MODULATING GLYCATIVE STRESS, OXIDATIVE STRESS AND INFLAMMATORY PATHWAYS. CREDIT: IMAGE COURTESY OF MOHAMED EL-SHERBINY, ALMAAREFA UNIVERSITY. New research conducted in rats suggests a compound that gives some cruciferous vegetables their pungent taste could help to reverse kidney problems associated with diabetes. It...
EXPERIMENTAL BIOLOGY IMAGE: PATRICIA A. LOZANO, A RESEARCH ASSISTANT AT THE TEXAS A&M UNIVERSITY RANGEL COLLEGE OF PHARMACY CREDIT: PATRICIA A. LOZANO The antidepression drug duloxetine could be beneficial to patients with both depression and cardiovascular disease, according to new studies performed in human blood and in mice. Globally, more than 300 million people have...
