TOKYO METROPOLITAN UNIVERSITY IMAGE: (top) Intracellular localization of RUNX2 and YAP in MSCs on gelatin gels with different elastic moduli. Notice how more signal is seen in a single location (the nucleus) for stiffer substrates. (bottom) Illustration of how localization of YAP and RUNX2 changes with substrate stiffness for different batches. Note the consistency between...
Myopia link to poor sleep, and screen time
FLINDERS UNIVERSITY New research from Flinders University in Australia indicates people with myopia are more likely to experience poorer sleep quality than people with normal vision. The study indicates that people with short-sightedness have more delayed circadian rhythms and lower production of melatonin, a hormone secreted in the brain and responsible for regulating sleep at night, compared...
A long-term study shows strong links between gestational diabetes during pregnancy and type-1 and type-2 diabetes later in life
EUROPEAN SOCIETY OF ENDOCRINOLOGY A 23 year study being presented at the 23rd European Congress of Endocrinology (e-ECE 2021), on Monday 24 May 2021 at 14:40 CET (http://www.ece2021.org), has found that women who experience gestational diabetes (GDM) when they are pregnant, are more prone to developing type-1 and type-2 diabetes later in life. The long-term...
Full-genome CRISPR screen reveals surprising ways neurons survive oxidative stress
UNIVERSITY OF CALIFORNIA – SAN FRANCISCO IMAGE: SUPER-RESOLUTION MICROSCOPY OF A NEURON SHOWS THE ACCUMULATION OF LIPIDS WITHIN LYSOSOMES THAT OCCURS WHEN THE GENE FOR PROSAPOSIN IS SUPPRESSED. CREDIT: UCSF When a single gene in a cell is turned on or off, its resulting presence or absence can affect the function and survival of the...
Cancer treatments may accelerate cellular aging
WILEY New research indicates that certain anti-cancer therapies may hasten cellular aging, where changes in the DNA of patients may contribute to greater inflammation and fatigue. The findings are published by Wiley early online in CANCER, a peer-reviewed journal of the American Cancer Society. Gene activity is often adjusted during life through epigenetic changes, or physical modifications to...
Octopus-inspired wearable sensor
AMERICAN CHEMICAL SOCIETY IMAGE: A GRAPHENE-BASED ADHESIVE BIOSENSOR INSPIRED BY OCTOPUS “SUCKERS ” IS FLEXIBLE AND HOLDS UP IN WET AND DRY ENVIRONMENTS. CREDIT: ADAPTED FROM ACS APPL. MATER. INTERFACES 2019, 11, 16951?16957 Wearable electronics that adhere to skin are an emerging trend in health sensor technology for their ability to monitor a variety of...
USC study reveals potential new treatment target in the fight against COVID-19
KECK SCHOOL OF MEDICINE OF USC IMAGE: IMAGES OF CELLS SHOWING CLOSE PROXIMITY (YELLOW) OF GRP78 (GREEN) WITH SPIKE PROTEIN OF SARS-COV-2 (RED) (LEFT PANELS) AND ACE2 (RED) (RIGHT PANELS). CREDIT: LEAD AUTHOR ANTHONY CARLOS, PHD The swift development of vaccines has provided a vital tool to combat the spread of the deadly SARS-CoV-2 virus,...
Supersensitive connection causes hatred of noises
NEWCASTLE UNIVERSITY A supersensitised brain connection has been identified in people who suffer from misophonia, an extreme reaction to “trigger” sounds. For the first time, researchers led by Newcastle University, have discovered increased connectivity in the brain between the auditory cortex and the motor control areas related to the face, mouth and throat. Publishing today, in the...
Researchers discover oligodendrocyte loss and subtype alteration in CTE brains
BOSTON UNIVERSITY SCHOOL OF MEDICINE (Boston)–Since 2008, researchers at Boston University School of Medicine (BUSM) and VA Boston Healthcare System have studied Chronic Traumatic Encephalopathy (CTE), a progressive brain disease associated with repetitive head impacts that has been diagnosed after death in the brains of American football players and other contact sport athletes as well as members...
Telomere length, a longevity measure, may be determined early in life
COLUMBIA UNIVERSITY’S MAILMAN SCHOOL OF PUBLIC HEALTH Telomeres are protective caps on DNA that shorten as we grow older. Now, one of the first studies to examine telomere length (TL) in childhood finds that the initial setting of TL during prenatal development and in the first years of life may determine one’s TL throughout childhood...