UNIVERSITY OF ILLINOIS AT CHICAGO IMAGE: GEL-COATED (RED) MESENCHYMAL STROMAL CELLS (YELLOW) CAN DEGRADE COLLAGEN (GREEN) OVER A DISTANCE IN THE PRESENCE OF TUMOR NECROSIS FACTOR-ALPHA. CREDIT: JAE-WON SHIN AND SING-WAN WONG/UIC Researchers at the University of Illinois Chicago have shown that even after lung tissue has been damaged, it may be possible to reverse fibrosis and promote...
Cell Reports publishes data supporting the importance of ion channel, Kv7.2/7.3 as a target in ALS
LAVOIEHEALTHSCIENCE CAMBRIDGE, Mass.–(BUSINESS WIRE)–QurAlis Corporation, a biotech company developing breakthrough precision medicines for ALS and other genetically validated neurodegenerative diseases, today announced the publication of an article in Cell Reportstitled Human Amyotrophic Lateral Sclerosis Excitability Phenotype Screen: Target Discovery and Validation by QurAlis founders Kasper Roet, Ph.D., Clifford Woolf, M.D., Ph.D., and Kevin Eggan, Ph.D., who pioneered a high-content, live-cell imaging...
Filipino-Americans: Vitamin D binding protein in thyroid cancer health disparities
IMPACT JOURNALS LLC IMAGE: Cell counting and invasion assays after DBP-upregulation. (A) Cell counting at 0, 24, 48, and 72 hrs. after DBP overexpression compared to empty vector used as a control, a significantly lower cell count noted at 48 and 72 hrs. (*p < 0.05; **p < 0.01; ***p < 0.001), respectively. (B) A...
Osteoarthritis linked to higher Parkinson’s disease risk
WILEY A study published in Arthritis Care & Research has uncovered an elevated risk of Parkinson’s disease in individuals with osteoarthritis. The retrospective study using Taiwan’s Longitudinal Health Insurance Database 2005 included 33,360 patients who were 50-64 years old and had osteoarthritis in 2002-2005. A comparison group consisted of 33,360 age- and sex-matched individuals without osteoarthritis. The osteoarthritis...
Cholesterol metabolite induces production of cancer-promoting vesicles
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, NEWS BUREAU IMAGE: ERIK NELSON AND HIS COLLEAGUES FOUND THAT A BYPRODUCT OF CHOLESTEROL METABOLISM CAUSES SOME IMMUNE CELLS TO SPEW OUT CANCER-PROMOTING SIGNALS. NELSON IS A PROFESSOR OF MOLECULAR AND INTEGRATIVE PHYSIOLOGY AT THE UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN. CREDIT: PHOTO BY L. BRIAN STAUFFER CHAMPAIGN, Ill. — Scientists working...
“phase separation” allows an RNA to tightly control the activity of a protein that regulates neurodegeneration and aging
UT SOUTHWESTERN MEDICAL CENTER IMAGE: IMAGE SHOWS CELLS WITH OIL DROPLET-LIKE ‘NORAD-PUMILIO BODIES’ IN RED AND NUCLEUS IN BLUE. CREDIT: MAHMOUD ELGUINDY CREDIT: MAHMOUD ELGUINDY DALLAS – June 9, 2021 – A phenomenon in which an RNA named NORAD drives a protein named Pumilio to form liquid droplets in cells, much like oil in water,...
Study of hyperhomocysteinemia in rats elucidates tracks to treating migraine
KAZAN FEDERAL UNIVERSITY IMAGE: Parameters of CSD at different cortical depths in rats from the control and hHCY groups. The average CSD amplitude (A), CSD half-duration (SD-T1/2,B), rise time (C), and CSD depolarization rate (D) in different cortical layers in the control (white circles) and hHCY (black circles) groups. Data are expressed as mean ±...
A new culprit in antibacterial resistance: cysteine persulfide
KUMAMOTO UNIVERSITY IMAGE: TOP: Β-LACTAM ANTIMICROBIAL AGENTS RUPTURE BACTERIA BY DESTROYING THEIR CELL WALLS. BOTTOM: THE RED TEXT IN THE STRUCTURAL FORMULA REPRESENTS THE Β-LACTAM RING, WHICH IS ESSENTIAL FOR BACTERICIDAL ACTION. CREDIT: PROFESSOR TOMOHIRO SAWA A joint research project based in Kumamoto University, Japan has developed a new, highly sensitive analytical method that can detect degraded β-lactam antibacterial...
Common mechanism found for diverse brain disorders
VANDERBILT UNIVERSITY MEDICAL CENTER IMAGE: JING-QIONG (KATTY) KANG, M.D., PH.D., ASSOCIATE PROFESSOR OF NEUROLOGY AND PHARMACOLOGY, VANDERBILT UNIVERSITY MEDICAL CENTER. view more CREDIT: VANDERBILT UNIVERSITY MEDICAL CENTER Researchers at Vanderbilt University Medical Center (VUMC) have identified a common mechanism underlying a spectrum of epilepsy syndromes and neurodevelopmental disorders, including autism, that is caused by variations in a gene...
Women’s mental health has higher association with dietary factors
by Binghamton University Credit: Pixabay/CC0 Public Domain Women’s mental health likely has a higher association with dietary factors than men’s, according to new research from Binghamton University, State University of New York. Lina Begdache, assistant professor of health and wellness studies at Binghamton University, had previously published research on diet and mood that suggests that a high-quality diet...