ERA-EDTA IgA nephropathy (IgAN) is a chronic kidney disease occurring in young adults and is one of the most common reasons for kidney transplantation in this age group. IgAN is the most common form of glomerulonephritis (GN), i.e., immunologically induced inflammation of the renal glomeruli. It is characterized by glomerular deposition of immune complexes containing...
Month: <span>June 2021</span>
Post
Study supports gene therapy as a promising treatment for soft bone disease
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE IMAGE: JOSÉ LUIS MILLÁN, PH.D., IS A PROFESSOR IN THE HUMAN GENETICS PROGRAM AT SANFORD BURNHAM PREBYS. CREDIT: SANFORD BURNHAM PREBYS LA JOLLA, CALIF. – June 7, 2021 – A preclinical study led by scientists at Sanford Burnham Prebys has established that AAV8-TNAP-D10–a gene therapy that replaces a key...
Post
New drug to halt dementia after multiple head injuries
UNIVERSITY OF SOUTH AUSTRALIA IMAGE: THE RED AREA SHOWS WHERE THE BRAIN IS INFLAMED AFTER CONCUSSION. CREDIT: UNIVERSITY OF SOUTH AUSTRALIA A world-first international study led by the University of South Australia has identified a new drug to stop athletes from developing dementia after sustaining repeated head injuries in their career. The link between concussion...
Post
Monash researchers make fundamental advance in understanding T cell immunity
MONASH UNIVERSITY IMAGE: THE IMAGE SHOWS A BRIGHTLY COLORED CANONICAL INTERACTION BETWEEN TCR AND PMHC WHICH IS CONDUCIVE TO SIGNAL TRANSDUCTION. THE FADED MIRROR IMAGE SHOWS A REVERSED TCR-PMHC INTERACTION WHICH IS UNABLE TO SUPPORT SIGNAL TRANSDUCTION AND THUS T CELL ACTIVATION. CREDIT: CREATED BY DR. ERICA TANDORI (ROSSJOHN LAB Monash University researchers have provided a fundamental...
Post
An ‘atlas’ of the brain’s choroid plexus across the lifespan
by Children’s Hospital Boston Cell types in the mouse embryonic choroid plexus, revealed by different stains. From left to right, choroid plexus from the lateral ventricle, third ventricle, and fourth ventricle. From the top, a pathologist’s view, followed by epithelial, endothelial, mesenchymal, and immune cells. Credit: Dani N, Herbst RH, et al. Cell April 30, 2021....
Post
Simple blood test can accurately reveal underlying neurodegeneration
by King’s College London Credit: CC0 Public Domain A new study of over 3000 people led by King’s College London in collaboration with Lund University, has shown for the first time that a single biomarker can accurately indicate the presence of underlying neurodegeneration in people with cognitive issues. Levels of a protein called neurofilament light chain...
Post
Researchers identify a molecule critical to functional brain rejuvenation
by CUNY Advanced Science Research Center In young adult mice (left), TET1 is active in oligodendroglial cells especially after injury and this leads to new myelin formation and healthy brain function. In old mice (right), the age-related decline of TET1 levels impairs the ability of oligodendroglial cells to form functional new myelin. The authors are currently investigating whether...
Post
New method of gene analysis prevents early death in familial hypercholesterolemia
by Karolinska Institutet Credit: Gerd Altmann, Pixabay Researchers at Karolinska Institutet have investigated how a newly developed algorithm in connection with gene analysis can be used to improve the possibilities of preventing premature vascular disease and death in individuals with the hereditary lipid disorder, familial hypercholesterolemia. The findings, published in the Journal of Internal Medicine, show how the...
Post
Gene research uncovers promising combination therapy for triple negative breast cancer
by McGill University Credit: McGill University Breast cancer is the leading cause of cancer death in women around the world, responsible for 1,700 deaths every day. Although the vast majority of breast cancers are treatable, the most aggressive subtype—triple negative breast cancer (TNBC) – has a high recurrence rate, a high potential for metastasis, and shows...
Post
Precision prevention for prostate cancer
by University of Delaware Aditya Dutta and research collaborators found that, under conditions of stress, the NKX3.1 gene, which is critical in prostate biology, moves to the mitochondria — the powerhouse of the cell — in order to protect against prostate cancer. Credit: University of Delaware The University of Delaware’s Aditya Dutta and collaborators are investigating the NKX3.1...