by Graduate Center, CUNY A new study from Malave et al. suggests that in the brains of L-Dopa-treated Parkinson’s patients the lack of Shh signaling to cholinergic neurons results in L-Dopa induced dyskinesia. Credit: Santiago Uribe-Cano. Levodopa, or L-dopa, is considered the most effective treatment for Parkinson’s disease today. After a few years of treatment, however,...
Marta Zaraska September 15, 2021 In 1950, at Staten Island’s Sea View Hospital, a group of patients with terminal tuberculosis were given a new antibiotic called isoniazid, which caused some unexpected side effects. The patients reported euphoria, mental stimulation, and improved sleep, and even began socializing with more vigor. The press was all over the case, writing about the sick “dancing...
THE WISTAR INSTITUTE IMAGE: WISTAR’S DR. RUGANG ZHANG CREDIT: THE WISTAR INSTITUTE PHILADELPHIA — (Sept. 21, 2021) —Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress...
WOLTERS KLUWER HEALTH September 21, 2021 – Can the weather affect pain from conditions like arthritis or migraine? It may sound like an old superstition – but on some standard quantitative sensory tests, weather-related factors do indeed affect pain tolerance, suggests a study in PAIN®, the official publication of the International Association for the Study of Pain (IASP). The journal ispublished in the...
by The Rosalind Franklin Institute Novel Coronavirus SARS-CoV-2 Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: National Institute of Allergy and Infectious Diseases, NIH A unique type of tiny antibody produced by llamas could provide a new frontline...
UNIVERSITY OF DELAWARE IMAGE: UNIVERSITY OF DELAWARE MATERIALS SCIENTIST XINQIAO JIA (CENTER) IS SPEARHEADING SOLUTIONS TO REPAIR DAMAGED VOCAL FOLDS AND SALIVARY GLANDS THROUGH TISSUE ENGINEERING. THE WORK INCLUDES CONTRIBUTIONS FROM UD RESEARCHERS, GRADUATE STUDENTS, AND POST-DOCTORAL RESEARCHERS, AMONG OTHER COLLABORATORS. PICTURED LEFT TO RIGHT ARE XIAOYU ZOU AND JIYEON SONG, XINQIAO JIA, AND ERIC...
by Thamarasee Jeewandara , Medical Xpress A facile strategy for the 3D printed personalized micromachines from patient blood–derivable biomaterials. Harvested blood from the patient can be rapidly and robustly processed to obtain blood plasma, albumin, and platelet lysate. We use these biomacromolecules to prepare the microfabrication precursor mixtures containing the photosensitizer rose bengal and magnetic...
by NIH/National Institute of Allergy and Infectious Diseases A transmission electron microscopic image of hepatitis virus particles. Credit: CDC/ E.H. Cook, Jr. In a new paper published in Nature, scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, describe the structure of a key protein on the surface...
by Josh Barney, University of Virginia Fig. 1: Elmo1−/− mice have reduced bone erosion in two models of osteoporosis. a Single-nucleotide polymorphisms (SNP)-disease and phenotype associations discovered via search of the GWASdb SNP-Disease and six other SNP-phenotype association databases. The data are plotted using a standardized p value. Databases used and specific SNPs are indicated in Supplementary...
by Rush University Medical Center Credit: CC0 Public Domain Aging takes a toll on the body and on the mind. For example, the tissue of aging human brains sometimes develops abnormal clumps of proteins that are the hallmark of Alzheimer’s disease. How can you protect your brain from these effects? Researchers at Rush University Medical Center have...
