by Jennifer Michalowski, University of Utah Health Sciences Figure 1. Activity of A-443654 in qHTS assays. (a) Molecular structure of A-443654. (b) Relative luciferase activity in SNCA-Luc (IC50=251 nM, triangles), CMV-luc (open circles) and viability (squares) of SNCA-luc cells measured after 24 hrs of treatment with A-443654 at the indicated doses. Credit: DOI: 10.1016/j.jbc.2021.101191 University of...
by Marla Paul, Northwestern University Credit: Pixabay/CC0 Public Domain Hypertension that leads to vascular dementia in older adults begins to impact the brain by middle age, reports a large new Northwestern Medicine study published in PNAS, the first to show the process begins so early. But in some middle-aged individuals with this damage, their brains reorganize to...
by Monash University Credit: Shutterstock Monash University researchers have shown for the first time that mesenteric (gut) lymphatic dysfunction is a potential cause of and therapeutic target for obesity and insulin resistance. The groundbreaking study, published in Nature Metabolism, identified a profoundly damaging cycle in which a high fat diet promotes dysfunction of the mesenteric lymphatics, that in turn leads to...
by Michigan State University This image is a 3-D volume rendering of a myenteric ganglion with enteric glia labeled in blue and MHC-II labeled in red. Credit: Aaron Chow and the Gulbransen Lab Food is essential for life—a daily source of calories and comfort. But for the more than 3 million adults in the United States...
by University of Bath Dr George Stothart from the University of Bath's Department of Psychology analyses Fastball EEG data. Credit: University of Bath A simple but revolutionary approach to early Alzheimer’s diagnosis is being pioneered by researchers through an initiative that could pave the way for improved outcomes for individuals who develop the disease in the future. The innovative research,...
by American Institute of Physics Schematic of the dynamic core hypothesis (a), with each circle representing a neuron or groups of neurons, and the links between them transient synchronization. Temporally evolving assemblies (b) can be represented as modules unfolding within a multilayer network. Credit: Sofía Morena del Pozo, Helmut Laufs, Vincent Bonhomme, Steven Laureys, Pablo Balenzuala,...
by Perelman School of Medicine at the University of Pennsylvania Credit: CC0 Public Domain A popular class of diabetes medications called GLP-1R agonists (Trulicity and Rybelsus) may also protect against glaucoma in diabetic patients, according to a new study led by researchers in the Scheie Eye Institute at the University of Pennsylvania’s Perelman School of Medicine. The findings...
by Osaka University E-NTPD8 in colonic epithelial cells maintains gut homeostasis through the hydrolysis of luminal ATP produced by commensal bacteria (left). An increased level of luminal ATP caused by a lack of E-NTPD8 modulates neutrophil physiology, such as prolonged survival through P2X4-mediated promotion of glycolysis. This can then aggravate colitis symptoms (right). Credit: Haruka Tani...
by Children’s Hospital of Philadelphia Hematopoietic precursor cells: promyelocyte in the center, two metamyelocytes next to it and band cells from a bone marrow aspirate. Credit: Bobjgalindo/Wikipedia Aplastic anemia (AA) is a life-threatening bone marrow disorder caused by the autoimmune destruction of hematopoietic stem and progenitor cells (HSPCs). Currently, the condition is a diagnosis of exclusion,...
by Josh Barney, University of Virginia Credit: Ziniu Chen, UVA Communications Promising news in the effort to develop drugs to treat obesity comes from University of Virginia scientists who have identified 14 genes that can cause weight gain and three that can prevent it. The findings pave the way for treatments to combat a health problem...
