TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE IMAGE: IN NORMAL NEURONS, ONLY CERTAIN PARTS ARE SPONTANEOUSLY ACTIVATED. LOSS OF FUNCTION OF MUTATIONS IN TSC1 OR TSC2 LEADS TO HYPERACTIVATION OF MTOR. HYPERACTIVATED MTOR INCREASES LTCC EXPRESSION AND CAUSES A LARGE CA2+ INFLUX UPON NEURONAL ACTIVATION IN TSC NEURONS. INCREASED CA2+ INFLUX CAUSES ABNORMAL AXONAL EXTENSIONS AND...
KOBE UNIVERSITY IMAGE: FREQUENCIES OF CARRIERS OF SLC12A3 MUTATIONS AND PREVALENCE OF GITELMAN SYNDROME IN EACH ETHNICITY AND DATABASE. CREDIT: MODIFIED VERSION OF A. KONDO ET AL. SCI REP. 2021. -Estimated prevalence by ethnicity using genome databases- Clinical Fellow KONDO Atsushi and Professor NOZU Kandai et al. of Kobe University’s Graduate School of Medicine have...
by Institute of Cancer Research Fig. 1: CSDE1 is a positive modulator of VSV replication. A Hep3B cells were transfected with no siRNA, Negative control siRNA, or with [s15373 + 15374 siRNA] (2 CSDE1-specific siRNA)46 and levels of CSDE1 assayed by western blotting 24 or 48 h later. (Representative of three separate experiments). B–D Forty-eight hours following transfection with siRNA...
by University of Cincinnati Credit: CC0 Public Domain A new study led by a University of Cincinnati researcher sheds light on risk factors for certain kinds of strokes among different racial and ethnic groups. Daniel Woo, MD, vice chair of research in UC’s Department of Neurology and a UC Health physician, was the principal investigator in a study published Aug....
by Robert Burke, University of Pennsylvania Credit: CC0 Public Domain Are older adults with dementia “rehabbed to death?” This is the contention of a perspective published in the New England Journal of Medicine, describing the downward cycle of rehospitalization leading to death that many of these older adults experience. Hospitalization is a particularly significant event for older...
by Kanazawa University Principle of new therapeutic treatment. Credit: Kanazawa University The RB1 tumor suppressor gene protein antagonizes uncontrolled growth of cancer by suppressing cell cycle progression but its function is repressed in most cancers. CDK4/6 represses this function by phosphorylating RB1. In contrast, drugs that inhibit CDK4/6 inhibit the phosphorylation of RB1 and restore the...
by Kelsie Smith Hayduk, University of Rochester Medical Center Figure 1. Multilevel latent profile analysis in perimenopausal women. DH, dominant hand; NDH, non-dominant hand; RAVLT, Rey Auditory Verbal Learning Test. Credit: DOI: 10.1080/13697137.2021.1892626 Menopause can mess with your memory, and a new study from the University of Rochester Medical Center has identified four profiles of cognitive...
by University of Toronto Credit: Pixabay/CC0 Public Domain An image of a beautiful beach conjures up certain sensations—one can imagine the warmth of the sun, and the sound of waves breaking on shore. But how does the human brain produce these impressions when an individual isn’t actually standing on a beach, basking in the sun’s rays...
A team of scientists from the Technion-Israel Institute of Technology says it’s found a way that to reverse the natural aging of immune system cells — and potentially make the elderly far more resistant to COVID-19 and other infections. The researchers identified the molecular pathway that the human body uses to create B cells, The...
UNIVERSITY OF BASEL VIDEO: PROFESSOR IVAN MARTIN EXPLAINS THE APPROACH TO USE CARTILAGE CELLS FROM THE NASAL SEPTUM TO REPAIR THE DAMAGED CARTILAGE IN THE OSTEOARTHRITIC KNEE. CREDIT: UNIVERSITY OF BASEL Cartilage cells from the nasal septum can not only help repair cartilage injuries in the knee – according to researchers from the University of...
