About one-fourth of people with diabetes develop painful foot ulcers, which are slow to heal due to low oxygen in the wound from impaired blood vessels and increased inflammation. These wounds can become chronic, leading to poor quality of life and potential amputation. Representative images of wounds treated with or without gel and oxygen-release microspheres...
Novel finding shows that brain cells conduct antidepressant action even in the absence of activity
Researchers are one step closer to understanding the physiology of antidepressant action in the brain. They have confirmed that even when brain cells are not active, they trigger protein production that affects the function of cells and neural circuits. Credit: Pixabay The work was conducted in the labs of Ege Kavalali, professor and acting chair of the...
First atomic-level imaging of lethal prions provides sharpened focus for potential treatments
Using cryo-electron microscopy, researchers at Case Western Reserve University School of Medicine and National Institutes of Health open door to new level of detail in study of abnormal proteins that cause untreatable neurodegenerative conditions The highest-ever resolution imaging of an infectious prion has provided the first atomic-level data of how these abnormal proteins are assembled to cause...
Closing the gate on manganese could open doors to new drugs to treat pneumonia
DOE/SLAC NATIONAL ACCELERATOR LABORATORY Most of us take for granted that our kids will make it to their fifth birthday, but nearly half a million children worldwide who are infected by Streptococcus pneumoniae bacteria each year never make it that far. Spread in droplets when we cough or sneeze, the bacteria can cause deadly pneumonia, meningitis and...
Discovery offers insight for development of cancer therapies targeting mutant p53
by Vanderbilt University Medical Center Credit: CC0 Public Domain The tumor suppressor protein p53 is mutated in more than half of all human cancers. Several drugs that potentially can restore mutant p53 to its normal cancer-killing function are in clinical investigation. However, much remains to be learned about various mutations that lead to a “loss of...
Both sucrose and high fructose corn syrup linked to increased health risks
by Trina Wood, UC Davis Study design, experimental testing days, and dietary protocol. Asp (Aspartame). SB (sweetened beverage). Dual energy x-ray absorptiometry (DEXA). *<2% added sugar. % = % of energy requirement. Credit: DOI: 10.1210/clinem/dgab508 Consuming sucrose, the more “natural form of sugar,” may be as bad for your health as consuming high fructose corn syrup, according to...
Hormone profiling could be used to improve survival rates for breast cancer
by RCSI University of Medicine and Health Sciences Survival analysis of a TMA of primary breast cancer stained immunohistochemically for AR (n = 844). A, Graphical representation of common cut-off points in AR IHC studies with the bulk of clinical data applying an AR protein expression >1% to denote a positive stain. Normal breast ducts...
Study finds telemedicine appointments reduce risk of further illness
by University of Texas Health Science Center at Houston A study led by Ricardo Mosquera, MD, with McGovern Medical School at UTHealth found telemedicine appointments reduce risk of further illness. Credit: Roger Castro/UTHealth Telemedicine appointments combined with in-person visits significantly reduced the risk of further illness for children with medically complex cases, according to results of...
J&J: Potential HIV vaccine falls short in mid-stage study
by The Associated Press This Feb. 24, 2021 photo shows a Johnson & Johnson logo on the exterior of a first aid kit in Walpole, Mass. A potential HIV vaccine being developed by Johnson & Johnson did not provide protection against the virus in a mid-stage study, the drugmaker said Tuesday, Aug. 31, 2021. J&J...
Houston Methodist researchers identify over 50 long-term effects of COVID-19
HOUSTON METHODIST IMAGE: LONG AFTER LEAVING THE HOSPITAL, SOME PATIENTS ARE LEFT WITH LINGERING SYMPTOMS LASTING FROM WEEKS TO MONTHS AFTER RECOVERING FROM COVID-19. CREDIT: HOUSTON METHODIST HOUSTON-(Aug. 30, 2021) – As COVID-19 hospitalizations once again soar in a fourth surge more than 18 months after the pandemic started, some patients continue to experience symptoms...