by University of Pennsylvania Credit: Pixabay/CC0 Public Domain A study of “dented” internal clocks seems to have provided evidence for a theory as to why people who work late or irregular hours are susceptible to weight gain and diabetes. High rates of shift workers gain weight and develop diabetes, which has been attributed to a...
by Massachusetts Institute of Technology Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID Many COVID-19 patients have reported symptoms affecting the ears, including hearing loss and tinnitus. Dizziness and balance problems can also occur, suggesting...
by Karolinska Institutet Effects of IL-26 on the activation state of neutrophils exposed to Klebsiella pneumoniae. Human blood neutrophils were exposed to live Klebsiella pneumoniae (multiplicity infection (MOI); 0.01) with and without additional stimulation by rhIL-26 (10 and 50 ng/mL) for 3 hours. The expression of CD11b, CD66b and p38 MAPK was assessed using flow...
by Lindsey Hendrix, Texas A&M University Credit: Pixabay/CC0 Public Domain There’s a new drug in development that could prevent the next global pandemic. Researchers at the Texas A&M University Health Science Center (Texas A&M Health) and University of Texas MD Anderson Cancer Center are testing PUL-042, an inhaled therapeutic that provides broad protection against a...
by Georgia State University Credit: Unsplash/CC0 Public Domain Multiple sclerosis (MS) is a chronic neurological disease that affects the body’s central nervous system. It can limit a person’s mobility, impair physical and cognitive functions, and increase the risk of falling, collectively compromising quality of life. Cognitive impairment has been particularly difficult for researchers to address,...
by Ellen Goldbaum, University at Buffalo UB researchers have leveraged the power of digital pathology and computational modeling to develop a new approach to detecting and quantifying podocytes, shown above, a specialized type of cell in the kidney that undergoes damaging changes during early stage kidney disease. Credit: NIH, National Institute of Diabetes and Digestive...
by Cristy Lytal, University of Southern California Figure 1. Structure-based design of selective CBX8 compounds. (A) Reported CBX7 compounds and their in vitro potency in an AlphaScreen competition assay. (B) Comparison of the alanine binding pocket size of CBX7 (top) and CBX8 (bottom). (C) Comparison of the aromatic cage region of CBX7 (top) and CBX8 (bottom). (D)...
by University of Pennsylvania 3D-model of DNA. Credit: Michael Ströck/Wikimedia/ GNU Free Documentation License Targeted mutations to the genome can now be introduced by splitting specific mutator enzymes and then triggering them to reconstitute, according to research from the Perelman School of Medicine at the University of Pennsylvania. Led by graduate student Kiara Berríos under the...
Laser-assisted in situ keratomileusis surgery, commonly known as LASIK or laser eye surgery, aims to correct vision by permanently reshaping the eye’s cornea using a laser. Although generally safe, not everyone is an ideal candidate for LASIK surgery. Post-surgery, some people may experience dry eye symptoms. LASIK surgery is a procedure that uses lasers to help...
Most cancer treatments produce a lot of senescent cells in the course of killing cancerous cells. This is thought to be the primary reason as to why cancer survivors have a reduced life expectancy and greater burden of age-related disease. Senescent cells secrete disruptive, inflammatory signals that harm tissue function when consistently present. Growing numbers of senescent cells in old tissues are an...
