by Public Library of Science G2019S LRRK2 induces iron accumulation in inflammatory microglia in vivo. Credit: Mamais A et al., 2021, PLOS Biology, CC-BY 4.0 (creativecommons.org/licenses/by/4.0/) A common gene mutation for Parkinson’s disease drives mislocalization of iron in activated microglia, according to a new study publishing December 16th in the open-access journal PLOS Biology, by Mark Cookson...
Breakthrough infections generate ‘super immunity’ to COVID-19, study suggests
by Erik Robinson, Oregon Health & Science University Daniel Streblow, Ph.D., holds a plate of plasma samples that contain COVID-19 antibodies, to be evaluated in OHSUs in-house COVID-19 testing lab. Researchers have been studying antibody testing approaches. Credit: OHSU/Kristyna Wentz-Graff Breakthrough infections greatly enhance immune response to variants of the virus that causes COVID-19, according...
Reverse strategy finds diagnostic marker of autoimmune disease
Instead of searching for proteins that the immune system reacts against in a specific autoimmune disease, researchers have taken the opposite approach to find diseases linked to a certain protein. By searching among patients with various skin diseases, they identified a disease linked to autoimmunity against the skin protein TGM1. The strategy, which is presented...
Brain power: researchers take a closer look at cognition in Parkinson’s
Twice a month, Siva Venkadesh calls his father, who has Parkinson’s disease, on the phone. His father is often incoherent in those conversations. But sometimes, “If he goes out for a walk and then talks to me right after, I can understand him very clearly,” said Venkadesh, a postdoctoral neuroscience researcher at the University of...
Gene that aids cancer cell proliferation is new target for deadly pulmonary hypertension
MEDICAL COLLEGE OF GEORGIA AT AUGUSTA UNIVERSITY IMAGE: (FROM LEFT) GRADUATE STUDENT ZSUZSANNA BORDAN, DRS. SCOTT BARMAN AND DAVID FULTON. CREDIT: MICHAEL HOLAHAN, AUGUSTA UNIVERSITY AUGUSTA, Ga. (Dec. 16, 2021) – A gene that is overexpressed in some aggressive cancers also appears to be key to the excessive cell proliferation that thickens the walls of pulmonary arteries...
RNA molecules with no apparent function represent a new therapeutic approach against fungal infection by Candida
INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA) IMAGE: GENERAL OVERVIEW OF ALL PAIRWISE INTRACHROMOSOMAL RELATIONSHIPS BETWEEN LNCRNAS OF THE STUDIED SPECIES. CREDIT: IRB BARCELONA Barcelona, 16 December, 2021- Fungi of the Candida genus cause diseases such as vaginal candidiasis (highly prevalent but not serious) and systemic candidiasis (rare but can be fatal in immunocompromised patients). Although some...
Greater exposure to nitrogen dioxide linked to higher levels of biomarkers of Alzheimer’s disease in the brain
BARCELONA INSTITUTE FOR GLOBAL HEALTH (ISGLOBAL) Investigators from the Barcelonaβeta Brain Research Center (BBRC), the research arm of the Pasqual Maragall Foundation, in collaboration with ISGlobal, have found an association between exposure to air pollution and higher levels of biomarkers of Alzheimer’s disease, particularly in individuals with elevated beta-amyloid deposition in the brain. The results...
For IBS, specific diets are less important than expected
CHALMERS UNIVERSITY OF TECHNOLOGY IMAGE: A LARGE STUDY FROM CHALMERS UNIVERSITY OF TECHNOLOGY AND UPPSALA UNIVERSITY, SWEDEN, SUGGESTS THAT GLUTEN AND CERTAIN TYPES OF CARBOHYDRATES CALLED ‘FODMAPS’ HAVE LESS EFFECT THAN EXPECTED ON IBS SYMPTOMS. NO EFFECT AT ALL COULD BE SEEN FOR GLUTEN AND ONLY A SMALL EFFECT FOR FODMAPS. ACCORDING TO THE METRIC...
Artificial intelligence accurately predicts who will develop dementia in two years
UNIVERSITY OF EXETER Artificial intelligence can predict which people who attend memory clinics will develop dementia within two years with 92 percent accuracy, a largescale new study has concluded. Using data from more than 15,300 patients in the US, research from the University of Exeter found that a form of artificial intelligence called machine learning...
Study finds few pediatric providers discuss transportation with their autistic patients
CHILDREN’S HOSPITAL OF PHILADELPHIA Philadelphia, December 16, 2021 – A collaborative study from the Center for Injury Research and Prevention (CIRP) and the Center for Autism Research (CAR) at Children’s Hospital of Philadelphia (CHOP) found that only 8% of pediatric healthcare and behavioral service providers feel prepared to assess whether their autistic patients are ready...