by Doug Bennett, University of Florida Molecular docking of sigma-2 receptor ligands that exhibit antiviral activity against SARS-CoV-2. (A), highly selective sigma-2 receptor agonist CM398 is shown as posed by AutoDock Vina to a model of the human sigma-2 receptor. (B), dual sigma-1 and sigma-2 receptor ligand AZ66 is shown as posed by molecular docking....
by US Army Medical Research Institute of Infectious Diseases Capsule removal from Bacillus anthracis by treatment with capsule depolymerase (capsule shown in red). Credit: Wilson J. Ribot, USAMRIID Scientists have demonstrated that modifying an enzyme produced by the bacterium that causes anthrax can protect mice from infection with the deadly disease. Their findings, published in...
by Harvard T.H. Chan School of Public Health Credit: Unsplash/CC0 Public Domain A newly discovered hormone named fabkin helps regulate metabolism and may play an important role in the development of both type 1 and type 2 diabetes, according to research led by the Sabri Ülker Center for Metabolic Research at Harvard T.H. Chan School of...
by UK Research and Innovation The newly discovered structure of clumped TDP-43, from the brains of people with ALS. Credit: B. Ryskeldi-Falcon/MRC Laboratory of Molecular Biology Scientists have determined for the first time the structure of the molecule associated with amyotrophic lateral sclerosis (ALS) and multiple other neurodegenerative diseases. The scientists at the Medical Research...
by Society for the Study of Addiction Credit: CC0 Public Domain Smoking is a major health problem among Black or African American adults, but few tools are tailored to help them quit. The iCanQuit smartphone application was more effective than a more conventional smartphone application (QuitGuide) at getting Black US adults who smoke to quit...
by National Eye Institute L-ORD patient RPE cell (borders are white) showing mutant protein CTRP5 (red) trapped inside the cell and partially in autophagosomes (green). Credit: Ruchi Sharma and Davide Ortolan (NEI) Scientists have discovered that gene therapy and the diabetes drug metformin may be potential treatments for late-onset retinal degeneration (L-ORD), a rare, blinding eye...
by American Heart Association Credit: CC0 Public Domain Environmental exposure to low-levels of the toxic metals arsenic, cadmium and titanium appears to increase the risk of plaque buildup in arteries in the neck, heart and legs, according to new research published today in the American Heart Association’s journal Arteriosclerosis, Thrombosis and Vascular Biology (ATVB). Traces of metal may...
by University of Michigan Credit: Justine Ross, Michigan Medicine When the body attempts to fight off an infection, immune cells called neutrophils may shoot out spider web-like networks of toxic proteins to help contain the invaders. However, when not properly regulated, these web-like neutrophil extracellular traps, or NETs, play a role in forming blood clots and...
by American Heart Association Credit: Pixabay/CC0 Public Domain Prescribing generic medications for heart and blood vessel diseases more frequently instead of brand-name medications in Medicare’s prescription drug program, called Part D, could save more than $600 million each year in the U.S., according to new research published today in Circulation: Cardiovascular Quality and Outcomes, an American Heart...
by University of New South Wales The scientists observed which acute myeloid leukaemia cells are most likely to form cancerous tumours. Credit: Shutterstock For the first time, research has shown cancer cellswith the same genetic blueprint won’t necessarily behave in the same way, with serious implications for how we target them. A Peter Mac-led study...
