by RIKEN Neurons in the CA2 region of the hippocampus, fluorescently labeled here in yellow, help to coordinate the consolidation of long-term memory. Credit: RIKEN Center for Brain Science A brain region in mice that plays a key role in coordinating the playback process that consolidates memories during sleep has been identified by RIKEN neuroscientists....
by Molly Chiu, Baylor College of Medicine Credit: Baylor College of Medicine The brain has a natural protective mechanism against Alzheimer’s disease, and researchers at Baylor College of Medicine, Texas Children’s Hospital, and collaborating institutions have discovered that gene variants associated with risk of developing the disease disturb the protective mechanism in ways that can...
by University of Chicago Medical Center Credit: Unsplash/CC0 Public Domain For women with ovarian cancer, there is a high rate of mortality, in part due to the ease of cancer cell spreading, or metastasis, in the abdominal cavity. Current treatments can be expensive and have proven to be ineffective against long-term survival in these patients....
by Ludwig Maximilian University of Munich Credit: CC0 Public Domain CD4+ T cells are important parts of the immune system and play a key role in defending the body against pathogens. As they possess a great variety of defense mechanisms against HIV in their resting state, they are infected only very rarely—but these few infected...
COVID-19 pandemic taught us to pay more attention to disinfection. For that we use various solutions, such as alcohol. But what if some surfaces disinfected themselves? Copper can do that and, according to a new study from the University of Waterloo a very thin copper-containing coating can do the trick. Back in antiquity people knew that...
Senescent cells accumulate with age. Researchers here provide evidence for yet another age-related decline to be added to the long list of issues in which this accumulation of senescent cells is an important contributing cause. In this case, the problem is the loss of regenerative capacity in muscle tissue that occurs with age. Can this...
OSAKA CITY UNIVERSITY IMAGE: THE COMBINATION OF THE GENERIC DRUG RIFAMPICIN AND THE DIETARY SUPPLEMENT RESVERATROL, AND THE INTRANASAL ADMINISTRATION OF THEM WITH A NASAL SPRAY, WOULD ENABLE SAFER AND MORE EFFECTIVE PROPHYLAXIS AGAINST DEMENTIA. CREDIT: TAKAMI TOMIYAMA Dementia is thought to occur when proteins called amyloid-β, tau, and α-synuclein accumulate in the brain and...
ELSEVIER Philadelphia, December 28, 2021 – In the central nervous system, microglial cells play critical roles in development, aging, brain homeostasis, and pathology. Recent studies have shown variation in the gene-expression profile and phenotype of microglia across brain regions and between different age and disease states. But the molecular mechanisms that contribute to these transcriptomic...
by University of Michigan Credit: Pixabay/CC0 Public Domain While researchers have identified several genes that drive prostate cancer, a new study published in Nature reveals the puppet master controlling the strings. The strings: Cancer-causing genes, or oncogenes, such as androgen receptor, FOXA1, ERG, and MYC. The puppet master: A chromatin remodeling complex called SWI/SNF, which controls the...
by Japan Advanced Institute of Science and Technology (Left) Schematic illustration depicting the developed microneedles, which absorb the interstitial fluid beneath the skin and release the pre-loaded drug. (Right) Side-view image of a microneedle loaded with rhodamine B (pink dye), which diffuses after piercing a porcine skin sample; the yellow dot lines indicate where the...
