by Bill Hathaway, Yale University Credit: CC0 Public Domain T cells, biology textbooks teach us, are the soldiers of the immune system, constantly on the ready to respond to a variety of threats, from viruses to tumors. However, without rest and maintenance T cells can die and leave their hosts more susceptible to pathogens, Yale...
New combined therapy helps extend lives of men with prostate cancer
by Cedars-Sinai Medical Center Credit: Unsplash/CC0 Public Domain Practice-changing research from Cedars-Sinai Cancer shows that a combination of androgen deprivation therapy—a commonly used hormone injection—plus pelvic lymph node radiation, kept nearly 90% of clinical trial patients’ prostate cancer at bay for five years. The findings were published in the peer-reviewed journal The Lancet. The study also...
Researchers link sugar-studded protein to Alzheimer’s disease
by Johns Hopkins University School of Medicine The same glycoform of RPTPζ carries CD33 and Siglec-8 ligands. A, equal aliquots of human cerebral cortex total protein extract from four donors (numbered) were resolved on replicate composite agarose–acrylamide gels and blotted to PVDF. One blot (upper panels) was double-label probed with CD33-Fc (red) and anti-RPTPζ (green)...
Protein supplement helps control Type 2 diabetes
by Newcastle University Kieran Smith in the lab with the protein shots. Credit: Newcastle University, UK Drinking a small amount of whey protein before meals has been shown to help people with type 2 diabetes control their blood sugars. In a study, which holds potential for dietary management of the condition, people with type 2...
I have mild COVID. Should I take the antiviral Paxlovid?
by Mark Morgan, Amanda Gwee, Jason Roberts, Nicole Allard and Tari Turner, The Conversation Credit: Shutterstock The COVID medication Paxlovid has been available in Australia on the Pharmaceuticals Benefits Scheme (PBS) since the start of May, with eligible patients directed to talk to their GP for a prescription. Paxlovid is an oral treatment for mild COVID, taken as...
Steroids Less Effective in Older-Onset Ulcerative Colitis
Heidi Splete May 10, 2022 Intravenous steroids were less effective in ulcerative colitis patients with older-onset disease, compared with younger-onset patients, according to data from nearly 500 individuals. A combination of rising ulcerative colitis rates and an aging population has driven an increase in older-onset UC worldwide, Shinji Okabayashi, MD, of Kyoto University, and colleagues wrote in a study...
Expanding telehealth possibilities: Performing virtual frailty exams in the home
by American Society of Hematology Credit: Unsplash/CC0 Public Domain According to a new study published today in Blood Advances, frailty assessments, a type of geriatric exam essential to predicting health outcomes in older adults with cancer, are both safe and feasible when conducted virtually. While providers often use in-person frailty screenings in clinic, such evaluations have...
A synthetic antibiotic may help turn the tide against drug-resistant pathogens
by Rockefeller University Credit: CC0 Public Domain A new antibiotic, synthesized at The Rockefeller University and derived from computer models of bacterial gene products appears to neutralize even drug-resistant bacteria. The compound, named cilagicin, works well in mice and employs a novel mechanism to attack MRSA, C. diff, and several other deadly pathogens, according to...
New research questions previous link between diabetes drugs and bone fractures
by American Society of Nephrology Graphical abstract: Journal of the American Society of Nephrology (2022). DOI: 10.2215/CJN.16171221 Sodium glucose transport-2 (SGLT-2) inhibitors, which reduce glucose reabsorption by the kidneys, can help control blood sugar levels and protect kidney health in patients with diabetic kidney disease; however, some large clinical trials have linked the medications to a higher...
App uses artificial intelligence to track healing wounds in real-time
Three U of A engineering students has developed a mobile app that tracks the progress of a healing wound. The app calculates whether treatments are working as they should be based on descriptions of size, depth, and shape along with more subjective impressions of pain and irritation, says programmer Connor Povoledo. Accurate tracking can predict...