by Cedars-Sinai Medical Center Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.110977 Investigators from Cedars-Sinai Cancer have discovered that cancerous tumors called soft-tissue sarcomas produce a protein that switches immune cells from tumor-attacking to tumor-promoting. The study, published today in Cell Reports, could lead to improved treatments for soft-tissue sarcomas. The researchers focused on the tumor microenvironment—an ecosystem...
Erectile dysfunction drugs could help in the treatment of esophageal cancer
by Cancer Research UK Graphical abstract. Credit: Cell Reports Medicine (2022). DOI: 10.1016/j.xcrm.2022.100541 A group of drugs commonly used to treat erectile dysfunction may be able to boost the effect of chemotherapy in esophageal cancer, according to new research. This research, published today (Tuesday) in Cell Reports Medicine, found that the drugs, known as PDE5 inhibitors can reverse chemotherapy...
New drugs with high abuse potential more likely to be approved, go to market to treat pain
by American Society of Anesthesiologists Credit: CC0 Public Domain “Despite the prevalence and societal costs of pain in the United States, investment in pain medication development is low, due in part to poor understanding of the probability of successful development of such medications,” said the authors of a study published online first in Anesthesiology. “The opioid...
Scientists unravel mystery of rare neurodevelopmental disorder, provide definitive diagnoses to 21 families worldwide
by Susan Murphy, Mayo Clinic Individuals with KCNK9 imprinting syndrome. A KCNK9 coding exons showing all variants by predicted protein change using ProteinPaint (St. Jude Children’s Research Hospital). The number in the circle represents the number of families described with the variant, no number = 1 family. Previously published variants are gray. B TASK3 protein topology schematic...
New treatment option shows promise in clearing HPV infection
by University of Texas Health Science Center at Houston Electron micrograph of a negatively stained human papilloma virus (HPV) which occurs in human warts. Credit: public domain Daily use of a mushroom extract supported the immune system in clearing human papillomavirus (HPV) infections, according to researchers with UTHealth Houston. The study was published today in Frontiers...
Feelings of detachment predict worse mental health outcomes after trauma
by McLean Hospital Following trauma, feeling detached from one’s surroundings may suggest a higher risk of later developing serious mental health conditions. Credit: McLean Hospital Results from the largest prospective study of its kind indicate that for individuals who experience trauma, the presence of dissociation—a profound feeling of detachment from one’s sense of self or...
What are PFAS, and why is the EPA warning about them in drinking water? An environmental health scientist explains
By Kathryn Crawford, The Conversation Credit: The Conversation “PFAS? What’s PFAS?” You may be hearing that term in the news as the federal government considers new rules and guidelines for the chemicals. Even if the acronym is new to you, you’re probably already familiar with what PFAS do. That’s because they’re found in everything from nonstick cookware to carpets to...
Breaking Barriers – the First Patient in the World Receives Moderna mRNA Trial Infusion for Glycogen Storage Disease at UConn Health
June 8, 2022 | Jennifer Walker – UConn Health Loveah Hernandez, a brave 20-year-old from Texas, is contributing to science as the first person in the world to receive the Moderna mRNA infusion as part of the Ba1ance Trial for GSD-Ia at UConn Health. Love Joy, a nurse at UConn Health takes Loveah Hernandez’s blood pressure. (photo credit,...
How digital tech can help people with asthma manage their meds and reduce the risk of attacks
by Amy Chan, The Conversation Digital technologies can help, but they may not be for everyone and some may work better than others. Credit: Shutterstock Modern medical science has made remarkable progress in the treatment of asthma. Inhalers containing steroids are particularly effective in preventing an asthma attack. But getting people to take these preventive medicines long-term...
Nanoparticle sensor can distinguish between viral and bacterial pneumonia
Anne Trafton | MIT News Office Publication Date: June 13, 2022 PRESS INQUIRIES Caption:MIT researchers have designed a sensor that can distinguish between viral and bacterial pneumonia infections. In the background, depictions of viruses are on the left, and bacteria on the right. Credits:Image: Jose-Luis Olivares, MIT, and iStockphoto Many different types of bacteria and...