JOHNS HOPKINS MEDICINE Among older adults with early stage — also known as preclinical — heart failure, uncontrolled diabetes can substantially increase the risk of heart failure progression, according to a new Johns Hopkins-led study. Researchers found that controlling diabetes early in the heart failure process has immense potential to significantly prevent the progression to...
Month: <span>June 2022</span>
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A new fast and reliable experimental model for vascular malformations leads to the identification of miransertib as a promising therapy option
JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE IMAGE: DR. GRAUPERA WITH THE MAIN RESEARCHERS OF THE PUBLICATION. LEFT TO RIGHT: ODENA VILALTA, LEONOR GOUVEIA, SANDRA CASTILLO, MARIONA GRAUPERA, HELENA SABATA, ANA ANGULO AND LAIA MUIXÍ. CREDIT: JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE Researchers from the Josep Carreras Leukaemia Research Institute find miransertib could reduce vascular malformations related to...
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Molecule that combines three distinct technologies against most aggressive type of brain cancer is tested
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO IMAGE: NANOSTRUCTURED LIPID CARRIERS CONTAINING DOCETAXEL AND FUNCTIONALIZED WITH BEVACIZUMAB MAGNIFIED 100,000 TIMES CREDIT: LEONARDO DI FILIPPO/UNESP A drug carrier able to reach the brain, bind to an aggressive type of tumor called glioblastoma multiforme, and release a chemotherapeutic agent has been tested for the...
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Scientists discover and characterize a novel membraneless organelle that could play a role in Alzheimer’s treatment
by University of California – Santa Barbara Membraneless organelle. Credit: UC Santa Barbara Researchers in UC Santa Barbara neuroscientist Kenneth S. Kosik’s lab have discovered a novel organelle—a previously unknown cell structure whose function it is to help clean up faulty proteins in times of stress and keep cells functioning in top condition. Optimizing this...
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Study finds few COVID-19 patients get rebound symptoms after Paxlovid treatment
by Mayo Clinic Credit: CC0 Public Domain Mayo Clinic researchers studied the outcomes of 483 high-risk patients treated for COVID-19 with a five-day oral regimen of nirmatrelvir and ritonavir, together marketed as Paxlovid. Only a handful developed COVID-19 rebound symptoms, and the researchers say more studies are needed to determine why. Overall, the treatment benefited...
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Streamlining stem cells to treat macular degeneration
ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE IMAGE: THE DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO RETINAL PIGMENT EPITHELIUM FOR THERAPEUTIC USE TO TREAT ACUTE MACULAR DEGENERATION. THE “SPOTLIGHTS” REPRESENT THE USE OF SINGLE-CELL RNA SEQUENCING TO REVEAL THE GENE EXPRESSION STATE OF CELLS AT EARLY, MID, AND LATE TIME POINTS OF RETINAL PIGMENT EPITHELIUM DIFFERENTIATION. CREDIT:...
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Study links sugar-sweetened beverage consumption with liver cancer
AMERICAN SOCIETY FOR NUTRITION Rockville, Maryland (June 14, 2022) — A study of more than 90,000 postmenopausal women found that those who consumed at least one sugar-sweetened beverage daily faced a 78% higher risk of developing liver cancer compared with people who consumed less than three servings per month of such beverages. “Our findings suggest sugar-sweetened...
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Researchers find that RNA exosome is key for B cell development
by UT Southwestern Medical Center Hematoxylin and eosin staining of a Skiv2l-deficient mouse lymph node. A normal lymph node should have large, organized B cell follicles along the cortex (outer edge). The Skiv2l-deficient lymph node is devoid of B cells and does not have any organized B cell follicles. Credit: UT Southwestern Medical Center New...
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Researchers discover mechanism linking mutations in the ‘dark matter’ of the genome to cancer
by Dana-Farber Cancer Institute Credit: Pixabay/CC0 Public Domain For many years, the human genome was viewed as a book of life in which sections of great eloquence and economy of expression were interspersed with vast stretches of gibberish. The legible sections contained the code for making cell proteins; the other regions, representing about 90% of...
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New potential diabetes treatment regenerates insulin-producing cells
By Michael Irving June 13, 2022 Researchers in Sweden have uncovered how a molecule could help regenerate insulin-producing cells in the body as a new potential diabetes treatment Depositphotos An emerging way to treat diabetes is to repair or replace the cells in the body that naturally produce insulin. Swedish researchers have now identified a...