by University of Queensland Credit: Pixabay/CC0 Public Domain A University of Queensland-led study has found millions of COVID-19 patients may have undiagnosed acute kidney injury (AKI). AKI is a condition where the kidneys suddenly fail to filter waste from the blood, which can lead to serious illness or even death. Existing data indicates approximately 20...
Biomarker in liquid biopsy for lung cancer appears more accurate in predicting immunotherapy response than tumor biopsy
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE New York, NY (June 2, 2022) — Mount Sinai researchers have validated for the first time that a simple blood test called a liquid biopsy could be a better predictor of whether cancer immunotherapy will be successful for a patient with lung cancer than an invasive...
Overlooked proteins may be key to better diagnosis of Alzheimer’s
UNIVERSITY OF CALIFORNIA – SAN FRANCISCO In a new study of Alzheimer’s disease, researchers at UC San Francisco have discovered that a relatively unstudied form of the tau protein associated with neurodegeneration may be a means for better diagnosis and treatment of the disease. The form of tau, which is broken into fragments that accumulates...
Scientists discover new clues to liver cancer progression
by National University of Singapore Credit: Pixabay/CC0 Public Domain A team of researchers from the College of Design and Engineering, the N.1 Institute for Health and the Cancer Science Institute of Singapore at the National University of Singapore has recently engineered in vitro tumor models to better understand the crosstalk between liver cancer cells and...
Could there be a link between the enteric neurons, gut microbiome and ALS?
by University of Illinois at Chicago Figure 1. SOD1G93A mice have slow intestinal mobility, decreased rotarod test time and grip strength during ALS progression. (a) SOD1G93A mice significantly increased gut transit time starting at 2-month-old compared to WT mice. In age-matched WT and SOD1G93A mice, intestinal mobility was tested using Evans blue marker (5% Evans blue, 5% gum...
New study shows bidirectional link between inflammatory bowel disease and depression
by University of Southern California Credit: CC0 Public Domain Inflammatory bowel disease (IBD) is a chronic condition involving inflammation of the digestive tract, affecting some 1.6 million Americans. Depression affects more than 16 million Americans. A new study from Keck Medicine of USC shows that patients diagnosed with IBD were nine times as likely to...
Evidence mounts for alternate origins of Alzheimer’s disease plaques
by NYU Langone Health Three images, as seen by fluorescent microscopy, show flower-like formations (at decreasing resolution) of autophagic vacuoles in neurons of Alzheimer’s disease mouse. Credit: Springer-Nature Publishing. A breakdown in how brain cells rid themselves of waste precedes the buildup of debris-filled plaques known to occur in Alzheimer’s disease, a new study in...
Exercise amplifies immune attack on pancreatic cancer
by NYU Langone Health Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer Institute Aerobic exercise reprograms the immune system to reduce pancreatic tumor growth and amplify the effects of immunotherapy, a new study finds. Published online in Cancer Cell June 2, the study provides new insight into how the mammalian immune...
Researchers ID gene critical to human immune response
by Cedars-Sinai Medical Center Credit: CC0 Public Domain Cedars-Sinai investigators have identified a gene that plays an essential role in the innate human immune system. The gene, NLRP11, helps activate the inflammatory response that tells the body’s white blood cells to go on the attack against a foreign presence. The findings, published in Nature Immunology, bring...
Researchers show that mutations in DNA can be corrected with short-term expression of gene editing tools
by Karolinska Institutet Left: Schematic drawing of the HGPS mutation correction by an adenine base editor (ABE), created with Biorender. Illustration: Daniel Whisenant. Right: 21 year old patient with Hutchinson-Gilford progeria syndrome. Credit: provided by The Progeria Research Foundation; informed consent obtained by The Progeria Research Foundation The most common mutation in the human genome...