by Karolinska Institutet Credit: CC0 Public Domain In a new study, researchers at Karolinska Institutet show that the activation of specific cell surface proteins—cortisol, estrogen and vitamin A—in mice with human neuroblastoma cells results in the neuronal differentiation of cancer cells which leads to reduced mortality. The results, published in the Journal of Experimental & Clinical...
by Daegan Miller, University of Massachusetts Amherst Lila Gierasch (center), professor of biochemistry and molecular biology at UMass Amherst. Credit: UMass Amherst In a major new development in the quest to develop better gene therapies with which to treat a host of diseases, researchers at the University of Massachusetts Amherst and UMass Chan Medical School recently...
by Atrium Health Wake Forest Baptist Bolus administration of 2 mg/kg 3,4-DAP reverses clinical signs of botulism and prolongs survival. A Summary of experimental models. B Median ± interquartile ratio (IQR) toxic signs for rats given a single injection of vehicle (black) or 3,4-DAP (pink) at 28 h after challenge with 0.44 ng/kg BoNT/A (2.5 LD50 BoNT/A; n = 4 per group)....
by Joslin Diabetes Center Credit: Pixabay/CC0 Public Domain In type 1 diabetes, the body develops immune cells that target pancreatic beta cells, which play a critical role in the production and secretion of insulin. One of the earliest targets of this immune response is a specific sequence of amino acids, or peptide, within the insulin...
UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS Researchers at the University of Colorado Anschutz Medical Campus have investigated how antiviral proteins called interferons interact with SARS-CoV-2, the cause of COVID-19. The study, published in Proceedings of the National Academy of Sciences USA, focuses on how the innate arm of the immune system defends against this coronavirus. The work resulted from...
SOCIETY FOR NEUROSCIENCE IMAGE: FEAR-POTENTIATED STARTLE INTERACTS WITH HIPPOCAMPAL THREAT REACTIVITY IN PREDICTING PTSD AT TWO-WEEKS. CREDIT: TANRIVERDI ET AL., JNEUROSCI 2022 After a traumatic event, people with decreased activity in the hippocampus experience worse PTSD symptoms, according to new research published in JNeurosci. The hippocampus does more than encode new memories — it also takes...
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE IMAGE: THE FIGURE SHOWS THAT BLACKS HAD A 2-FOLD INCREASED RISK FOR EARLY LOSS ARCHETYPES COMPARED TO NON-HISPANIC WHITES. BLACKS HAD A 5-FOLD INCREASED RISK OF ADVANCED LOSS ARCHETYPES. THE DIFFERENCE IN INCREASED RISK FOR BLACKS BETWEEN THE ADVANCED LOSS ARCHETYPES VERSUS THE EARLY LOSS...
By Michael Irving July 24, 2022 A new study uncovers a potential mechanism for fighting drug-resistant cancers Depositphotos Scientists in Spain have uncovered a mechanism behind why some cancer patients don’t respond well to treatments – and more importantly, found a “weak spot” that could be targeted by existing drugs. Frustratingly, many cancer patients don’t...
By Michael Irving July 24, 2022 A new study could help restore insulin production to the pancreas of patients with type 1 diabetes Depositphotos Australian scientists have demonstrated a new way to restore insulin production in pancreatic cells, using a drug that’s already approved for use in humans. The study could mark a major breakthrough...
Studying speakers of 45 languages, neuroscientists found similar patterns of brain activation and language selectivity. Over several decades, neuroscientists have created a well-defined map of the brain’s “language network,” or the regions of the brain that are specialized for processing language. Found primarily in the left hemisphere, this network includes regions within Broca’s area and...
