Memory loss is a common symptom after a stroke, but there’s hope for some that those memories could return. A new study from Norway examined 86 patients with relatively mild strokes and found many had improved mental functioning after 12 weeks. “Our study shows that around half of patients suffering a stroke had various forms of memory...
Study reveals new mode of triggering immune responses
by Weill Cornell Medical College Confocal microscopy image shows that DNA (green) and the chemokine CXCL4 (red) colocalize (indicated by yellow areas) during inflammatory responses in the skin. Credit: Barrat lab Small proteins, called chemokines, that direct immune cells toward sites of infection can also form DNA-bound nanoparticles that can induce chronic, dysfunctional immune responses, according...
New study evaluates pharmacological treatment for insomnia
by University of Oxford Credit: CC0 Public Domain Two drugs, eszopiclone and lemborexant—both not currently licensed for the treatment of insomnia in the UK—were shown to perform better than others, both in the acute and long-term treatment of insomnia in adults, according to a new Oxford study exploring the pharmacological management of insomnia. The new study,...
Scientists zero in on genetic causes of Parkinson’s
Variants of at least 20 different genes have been closely linked to the development of Parkinson’s disease. However, scientists are still investigating how exactly they cause the severe and incurable motor disorder afflicts about 1 million people in the U.S. alone. Image credit: Claudia Love on Unsplash, free license New research by Yale researchers offers essential...
NICE recommends Rhythm’s ▼IMCIVREE(R) (setmelanotide) for treating obesity and controlling hunger caused by POMC or LEPR deficiency
EMOTIVE BOSTON, USA, Monday 18th July, 2022 – Rhythm Pharmaceuticals, Inc. (Nasdaq: RYTM), a commercial-stage biopharmaceutical company focused on transforming the lives of patients and their families living with hyperphagia and severe obesity caused by rare melanocortin-4 receptor (MC4R) pathway diseases, today announced that the National Institute for Health and Care Excellence (NICE) has issued guidance...
Synthetic tools conduct messages from station to station in DNA
RICE UNIVERSITY IMAGE: RICE UNIVERSITY BIOENGINEERS ARE USING DEACTIVATED CAS9 PROTEINS TO TARGET KEY SEGMENTS OF THE HUMAN GENOME AND SYNTHETICALLY TRIGGER THE TRANSCRIPTION OF HUMAN GENES. CREDIT: ILLUSTRATION BY SOFIA ESCOBAR/RICE UNIVERSITY HOUSTON – (July 18, 2022) – Rice University researchers have demonstrated that CRISPR-Cas9, increasingly famous as a gene-editing tool, can be employed in...
New imaging method could lead to diagnosis of early stage Parkinson’s disease
by Hebrew University of Jerusalem MRI images used for automatic detection of microstructural changes in early-stage Parkinson’s Disease (PD) patients. Marked in yellow are areas in the putamen where PD patients show tissue damage, compared to healthy controls. Credit: Mezer Lab/Hebrew University Parkinson’s is a progressive and debilitating disease of the brain that eventually compromises patients’...
The retron switch
EUROPEAN MOLECULAR BIOLOGY LABORATORY IMAGE: THE RESEARCHER’S TAC/TIC APPROACH IS ABLE TO IDENTIFY WHAT FLIPS THE SWITCH TO ACTIVATE A RETRON’S TOXINS TO PREVENT A VIRAL SPREAD CREDIT: CREATIVE TEAM/EMBL Since first discovered in the 1980s, retrons have puzzled researchers who simply wanted to know what these bacterial DNA sequences actually did. Now, EMBL scientists...
New insights into melanoma brain metastases
by Columbia University Irving Medical Center Credit: Pixabay/CC0 Public Domain Brain metastasis is one of the most common causes of cancer-related deaths and occurs very frequently in patients with advanced melanoma. Although new immunotherapies are effective in some patients with melanoma brain metastases, little is known about the reasons for melanoma’s spread to the brain...
Blood-based biomarkers as a promising tool for early detection of incipient tuberculosis in people living with HIV
by Philipp Kressirer, LMU University Hospital Munich Frequencies of CD38+ MTB-specific IFNγ+ CD4 T cells over time in AFRICOS study participants with LTBI, incipient TB and active TB. The figure shows the frequencies of MTB-specific CD4 T cells that express CD38 (as % IFNg+ cells) over time using the indicated color code. (A) shows CD38+...