by Ashwin Swaminathan, The Conversation Credit: Unsplash/CC0 Public Domain My glorious two and a half year run of negative COVID tests came to a shuddering halt last week, after receiving a text confirming I was among the pandemic’s latest catch. My case adds to the rising slope of the third omicron wave in seven months, currently rolling...
by Cleveland Clinic Immune microenvironment of the post-treatment Pole mutant tumors. a, Differentially expressed genes up-regulated or down-regulated in the post-ICB PoleP286R tumors versus the parental tumors. There are 82 DEGs that are consistently upregulated in all ICB treatment arms, while there are 59 genes are consistently downregulated in mutant tumors of all immune checkpoint...
by University of Nottingham Rationale of the ELK1-GO membrane reduction process and application. Illustration depicting a). exposure of 70% ethanol to an ELK1-GO complex comprising stacks of GO. b). ELK1-GO complexes form multi-layered ELK1-GO membranes, which are co-assembled at the interface of a GO solution and an ELK1 solution. c). Ethanol molecules penetrate the ELK1...
by CORDIS Credit: Explode, Shutterstock When cancer cells break away from the original tumor in metastatic—stage IV—breast cancer, they usually spread to the bones, liver or lungs. A new study, associated with the MetEpiStem project, describes what happens to metastatic breast cancer cells when they migrate from the primary site in the breast to soft...
By CALIFORNIA INSTITUTE OF TECHNOLOGY JULY 8, 2022 An artist’s depiction of a bacterial cell. Credit: Centers for Disease Control and Prevention/James Archer Since its inception, chemotherapy has proven to be a valuable tool in treating many kinds of cancers, but it has a significant drawback. In addition to killing cancer cells, it can also destroy healthy...
by Lindsey Hendrix, Texas A&M University Credit: CC0 Public Domain As most Americans wind down for bed, 15 million people are just clocking into work. These hospital workers, emergency responders, factory operators and others are among the 20 percent of the world’s population who do shift work. Their different sleep-wake cycle elevates their risk for...
by Hudson Institute of Medical Research TLR-induced inflammasome priming triggers IL-1β and NLRP3 ubiquitylation. a BMDMs were primed with Lipopolysaccharide (LPS, 50 ng/ml) for up to 8 h (hr) and ubiquitylated (Ub.) proteins were isolated from cell lysates by Tandem Ubiquitin Binding Entity (TUBE) purification. Immunoblots were performed on cell lysates (input) and purified ubiquitylated proteins (TUBEs) for the...
by Wolters Kluwer Health Credit: CC0 Public Domain For men with moderate erectile dysfunction (ED), a non-invasive technique called low-intensity shockwave therapy (LiST) leads to significant improvement in sexual function, concludes a clinical trial in the Journal of Urology. “Our findings suggest LiST is highly effective and safe in patients with moderate vasculogenic ED,” write Nikolaos...
by British Medical Journal Credit: Pixabay/CC0 Public Domain Thousands of people experiencing the debilitating symptoms of long COVID are traveling abroad to seek costly but unproven treatments such as “blood washing,” according to an investigation carried out by The BMJ and ITV News and released today. Patients are traveling to private clinics in Cyprus, Germany and Switzerland...
by Nadine A Yehya, UC Davis Credit: Unsplash/CC0 Public Domain An international team of researchers led by UC Davis geneticist Suma Shankar has discovered a new gene implicated in a neurodevelopmental condition called DPH5-related diphthamide-deficiency syndrome. The syndrome is caused by DPH5 gene variants that may lead to embryonic death or profound neurodevelopmental delays. Findings...
