Month: <span>July 2022</span>

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Researchers develop C. elegans as a model for investigating metabolism variations between individuals
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Researchers develop C. elegans as a model for investigating metabolism variations between individuals

by Jim Fessenden, University of Massachusetts Medical School Caenorhabditis elegans. Credit: Kbradnam at English Wikipedia/Wikimedia Commons, CC BY-SA 2.5 Using four unrelated strains of the microscopic nematode C. elegans originating from different parts of the world, a group of worm biologists have developed a model system to study individual differences in metabolism. The use of C. elegans, a widely...

Study unveils pro-inflammatory interactions in drug-resistant epilepsy
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Study unveils pro-inflammatory interactions in drug-resistant epilepsy

by Ingrid Fadelli, Medical Xpress Microglia and infiltrating immune cells in brain tissue from patients with DRE. Position and phenotype of clusters on the t-SNE map. Color represents the cluster ID. Credit: Kumar et al, Nature Neuroscience (2022). DOI: 10.1038/s41593-022-01095-5 Epilepsy is a common condition that causes those affected to experience frequent seizures, which are bursts of...

Deconstructing the mechanics of bone marrow disease
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Deconstructing the mechanics of bone marrow disease

by Benjamin Boettner, Harvard University The team developed an alginate-based hydrogel system that mimics the viscoelasticity of the natural extracellular matrix in bone marrow. By tweaking the balance between elastic and viscous properties in these artificial ECMs, they could recapitulate the viscoelasticity of healthy and scarred fibrotic bone marrow, and study the effects on human...

Are eggs dairy? Why people might think so
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Are eggs dairy? Why people might think so

Although commonly grouped together, eggs are not dairy products. Dairy products come from the milk of mammals such as cows, whereas eggs come from birds such as hens or ducks. People may think eggs are dairy because retailers often sell the two products close together, and people may group them together because they are both animal products...

Programmed cell death in cancer cells: Overcoming resistance through paraptosis-inducing compounds
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Programmed cell death in cancer cells: Overcoming resistance through paraptosis-inducing compounds

TOKYO UNIVERSITY OF SCIENCE IMAGE: RESEARCHERS FROM TOKYO UNIVERSITY OF SCIENCE HAVE DEVELOPED NOVEL COMPLEX-PEPTIDE HYBRIDS, WHICH CAN INDUCE A TYPE OF PROGRAMMED CELL DEATH CALLED “PARAPTOSIS” IN APOPTOSIS-RESISTANT CANCER CELLS. CREDIT: TOKYO UNIVERSITY OF SCIENCE Apoptosis, a type of programmed cell death (PCD), is a biological process through which unwanted cells are eliminated in...

Poziotinib is active in EGFR exon 20 mutant non-small cell lung cancer
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Poziotinib is active in EGFR exon 20 mutant non-small cell lung cancer

by University of Texas M. D. Anderson Cancer Center Credit: Pixabay/CC0 Public Domain A Phase II clinical trial of poziotinib for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 mutations, led by researchers at The University of Texas MD Anderson Cancer Center, found the drug had significant antitumor activity and...

Being vaccinated may lower stroke risk in adults with flu-like illnesses
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Being vaccinated may lower stroke risk in adults with flu-like illnesses

by Laura Williamson, American Heart Association News  Flu-like illnesses can increase the risk for stroke among adults, but being vaccinated might lower those odds, especially among those under 45, new research finds. The study, published Monday in the American Heart Association journal Stroke, found flu-like illnesses increased the odds of having a stroke in the month following infection,...

Discovery of molecular pathway through which stress affects lupus
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Discovery of molecular pathway through which stress affects lupus

by Hokkaido University When mice that exhibit SLE-like symptoms are subjected to sleep deprivation stress, their neurons exhibit abnormal growth (left). When IL12 and 23 are blocked, the abnormal growth is reversed (right). Credit: Nobuya Abe et al, Annals of the Rheumatic Diseases (2022) Systemic lupus erythematosus (SLE) is an autoimmune disease that affects all the organ...