by Scott LaFee, University of California – San Diego In mouse models, researchers found that how much animals ate and when altered their gut microbiome, sometimes for the worse. Credit: Public domain (original work of U.S. Federal Government) An estimated 500 to 1,000 bacterial species reside in each person’s gut, perhaps numbering 100,000 trillion microorganisms....
Novel oral nano-in-micro system provides efficient curcumin delivery to alleviate ulcerative colitis
By Dr. Priyom Bose, Ph.D. Jul 5 2022Reviewed by Aimee Molineux Ulcerative colitis (UC) is an inflammatory disease of the distal colon, which affects the gastrointestinal tract. This disease persists for a prolonged period and is often recurring. Patients with UC require long-term treatment to control disease progression. Several types of drugs, such as salicylic...
Highly scalable multi-pronged intervention could cut hypertension-linked morbidity, mortality globally
by Federico Graciano, Duke-NUS Medical School Mean SBP and proportion BP controlled by treatment group over time. Panel A: Mean SBP was estimated with a generalized linear MMRM for SBP, with cluster random effects for clinic, and random effects for participants. The I bars indicate 95% CIs. *The p-value for the difference in the mean SBP...
Earliest Date Guidelines to Make Your Day Memorable
First occassions can be malaysia cupid a lot of fun but can also truly feel stressful. Whether you’re looking for the right date idea to break the ice or really want to find unique approach to connection with someone new, there are various fun facts you can apply to make your date memorable. Taking your...
RARE THYMOCYTE CELLS CAN TURN INTO BLOOD CANCER
T-cell acute lymphoblastic leukemia, or T-ALL, affects more than 6,000 Americans each year. Researchers characterized the thymocyte cells—an immune cell present in the thymus—while studying mice with T-ALL. They determined all of the rodent tumors originated from the same type of T cell that expresses a unique set of molecular markers. “Once we identified the cell in...
Sperm screening might detect harmful mutations before embryo implantation
ELIFE Screening sperm may help identify potentially harmful new genetic mutations and help fertility specialists prevent them from being passed on to offspring, shows a preliminary study published in eLife. The results suggest a potential tool to help improve fertility treatment outcomes. New harmful disease-causing mutations can arise in sperm, and fathers may inadvertently pass...
Nanoparticle vaccine protects against a spectrum of COVID-19-causing variants and related viruses
CALIFORNIA INSTITUTE OF TECHNOLOGY IMAGE: THIS INFOGRAPHIC ILLUSTRATES THE NEW VACCINE, COMPOSED OF RBDS FROM EIGHT DIFFERENT VIRUSES. THE TABLE SHOWS THE BROAD SPECTRUM OF SARS-COV-2 VARIANTS AND RELATED CORONAVIRUSES THAT THE VACCINE INDUCES PROTECTION AGAINST. CREDIT: COURTESY OF WELLCOME LEAP, CALTECH, MERKIN INSTITUTE A new type of vaccine provides protection against a variety of...
Study shows convalescent plasma doesn’t benefit severely ill patients hospitalized with COVID-19
VANDERBILT UNIVERSITY MEDICAL CENTER IMAGE: WESLEY SELF, MD, MPH, ASSOCIATE PROFESSOR OF EMERGENCY MEDICINE, VICE PRESIDENT FOR CLINICAL RESEARCH NETWORKS AND STRATEGY AT VUMC AND LEAD AUTHOR OF THE STUDY. CREDIT: VANDERBILT UNIVERSITY MEDICAL CENTER Convalescent plasma, widely given to severely ill patients hospitalized with COVID-19 during the pandemic, does not improve their ability to...
Peptide with anti-obesity action is successfully tested in animal trial
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO IMAGE: CHEMICAL STRUCTURE OF PEP19 CREDIT: RESEARCHERS’ ARCHIVE A study conducted at the University of São Paulo (USP) in Brazil shows that the synthetic molecule Pep19 acts on the endocannabinoid system, which helps regulate and balance key metabolic functions, such as appetite, fat breakdown (lipolysis),...
Molecule boosts fat burning
UNIVERSITY OF BONN IMAGE: HUMAN BROWN ADIPOCYTES, LIPID STAINED RED (REDO OIL STAIN) CREDIT: © LAIA REVERTE SALISA / UNIVERSITY OF BONN Normally, fat cells store energy. In brown fat cells, however, energy is dissipated as heat – brown fat thus serves as a biological heater. Most mammals therefore have this mechanism. In humans it...