by Duke University Credit: Pixabay/CC0 Public Domain A genetic risk for heart disease is far less predictive of problems than actual lifestyle risk factors such as high blood pressure, high cholesterol and diabetes—even among younger adults. In a finding published July 26 in the journal Circulation, researchers led by a team at Duke AI Health found...
Liam Davenport July 11, 2022 When anti–tumor necrosis factor-alpha (anti-TNF) treatment fails to achieve remission for patients with ulcerative colitis (UC), tofacitinib (Xeljanz) appears more effective sooner than vedolizumab (Entyvio), suggests a Dutch registry study. Data on nearly 150 patients with UC who had already undergone treatment with anti-TNF drugs showed that combined clinical and biochemical remission was about five times more likely...
Interview conducted by Emily Henderson, B.Sc. Jul 26 2022 In this interview, we speak to Echo Pan, a Ph.D. student from North Carolina State University about her latest research that used CRISPR to uncover more on probiotics. Please could you introduce yourself and tell us about what inspired your latest research into probiotics? My name...
Even before the COVID-19 pandemic, mental health challenges were the leading cause of poor life outcomes in young people. As many as 1 in 5 US children aged 3 to 17 have a mental, emotional, developmental, or behavioral disorder, according to the Centers for Disease Control and Prevention. Now, that crisis has grown. Symptoms of...
Stanford medical student Blynn Shideler created a wearable device for children with cerebral palsy that could provide therapy for young patients everywhere. Medical student Blynn Shideler arrived at Stanford with an award-winning health device – and every intention of improving it. The device addresses a need in the cerebral palsy community. Children with cerebral palsy...
Patients with indwelling urinary catheters often suffer from urinary tract infections, which can be challenging to treat. Now, researchers at Karolinska Institutet have discovered that the synthetic peptide CD4-PP has an excellent bactericidal effect against urinary tract bacteria, even those resistant to antibiotics. The study, published in the journal Cellular and Molecular Life Sciences, opens up for...
1,2-dichloropropane (1,2-DCP) is a solvent used in the printing industry. It was linked to cholangiocarcinoma in 2013, when printing company employees exposed to 1,2-DCP were diagnosed with the cancer. To understand the genes influencing cholangiocarcinoma development, scientists examined gene expression profiles in co-cultured cholangiocytes and macrophages exposed to 1,2-DCP. They found DNA repair genes in...
The findings of a large-scale screen could help researchers design nanoparticles that target specific types of cancer. Using nanoparticles to deliver cancer drugs offers a way to hit tumors with large doses of drugs while avoiding the harmful side effects that often come with chemotherapy. However, only a handful of nanoparticle-based cancer drugs have been FDA-approved. A...
Nerve cells regulate and routinely refresh the collection of calcium channels that enable them to send messages across circuit connections. The nervous system works because neurons communicate across connections called synapses. They “talk” when calcium ions flow through channels into “active zones” that contain vesicles carrying molecular messages. The electrically charged calcium causes vesicles to “fuse” to...
UNIVERSIDAD COMPLUTENSE DE MADRID UCC-UCM, 26 July 2022. In subjects who are cognitively healthy but have a high genetic risk of developing Alzheimer’s, correlations have been demonstrated between the retina and various brain structures which suffer changes as a result of the disease, such as the entorhinal cortex, the lingual gyrus and the hippocampus. This is the...
