by Bob Yirka , Medical Xpress RNA edQTL map in human tissues. Credit: Nature (2022). DOI: 10.1038/s41586-022-05052-x A team of researchers at Stanford University, working with two colleagues from Fudan University and another from the Broad Institute of MIT and Harvard, has found evidence suggesting that genetic variants that dampen A-to-I RNA editing can be associated with...
by Cell Press Non-nutritive sweeteners affect human microbiomes and can alter glycemic responses. Credit: Cell/Suez et al. Since the late 1800s non-nutritive sweeteners have promised to deliver all the sweetness of sugar with none of the calories. They have long been believed to have no effect on the human body, but researchers publishing in the...
by Medizinische Hochschule Hannover Spectrum of TP53 germline variants and statistically significant genotype-phenotype correlations. Colored spheres refer to different patients harboring the corresponding variant. Note: Y103* is based on two different nucleotide substitutions; whole gene deletions include two gross deletions with differing breakpoints. The genotype–phenotype correlation was based on data from 94 families. CNV, Copy number...
by German Cancer Research Center Credit: CC0 Public Domain Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Hebrew University in Jerusalem have identified in mice the cell of origin of combined liver/biliary duct carcinomas, a rare type of cancer of the liver. The pro-inflammatory immune messenger interleukin 6 (IL-6) was found...
by American Chemical Society Credit: Pixabay/CC0 Public Domain Although many people with dietary allergies experience mild symptoms when exposed to triggering foods, some face potentially fatal consequences. A bacterial compound called butyrate that’s made by healthy microbiomes has shown promise against allergic reactions in lab tests, but it’s nasty to take orally. Today, scientists describe...
by University of California, Los Angeles Trends in the use of glyphosate compounds, oxyfluorfen, paraquat dichloride, naled, and benomyl in California, 1979-2012. Credit: The Journal of Clinical Endocrinology & Metabolism (2022). DOI: 10.1210/clinem/dgac413 In single pollutant models and within a 20-year period, 10 out of 29 reviewed pesticides were associated with thyroid cancer, including several of the most...
Chronic neuropsychiatric symptoms are observed following COVID-19 infection, although self-reported symptoms are not associated with quantitative dysfunction, according to a study published in the October issue of Brain, Behavior & Immunity: Health. Alex K. Chen, from the Medical College of Georgia at Augusta University, and colleagues recruited COVID-19-positive adult patients (50 percent African American) from inpatient...
by Harvard Medical School Inflammation is the body’s first line of defense, occurring as droves of immune cells rush to the site of injury or acute illness to make repairs and stem further damage. When successful, inflammation helps the body survive and heal after trauma. However, when the recovery following an inflammatory response goes awry, it signals...
by Imperial College London Credit: Pixabay/CC0 Public Domain Fresh fruit and vegetables prescribed by doctors could be an effective way to improve the health of Australians with type 2 diabetes, according to a new study published today in the Journal of Nutrition. Researchers at The George Institute for Global Health and UNSW Sydney found that people...
by Bob Yirka, Medical Xpress Haplotypes associated with PD result in increased expression of GPNMB, encoding GPNMB. GPNMB interacts with aSyn, with effects on aSyn expression at the synapse, cellular uptake of fibrillar aSyn, and development of aSyn pathology in neurons. Together, these cellular processes mediate risk for development and progression of PD. Created with...
