by Simons Foundation Credit: Pixabay/CC0 Public Domain In a series of articles published in the journal Nature Genetics, researchers have used data from the SPARK (Simons Powering Autism Research) research cohort, which was created to advance our understanding of the complex genetics of autism and includes genetic data from nearly 43,000 people with autism. The findings...
Reduction in brain tissue oxygenation placing older adults with multiple health conditions at risk of faints and falls
TRINITY COLLEGE DUBLIN Researchers from Mercer’s Institute for Successful Ageing (MISA) and the Department of Medical Physics at St James’s Hospital and Trinity College Dublin have discovered that brain tissue oxygenation is lower in frailer older adults with multiple health conditions (multi-morbidity), putting them at risk of faints and falls. Brain oxygenation – the measure...
Report outlines most common symptoms of 6 cardiovascular diseases
AMERICAN HEART ASSOCIATION DALLAS, Aug. 18, 2022 — A review of the latest research highlights the most reported symptoms of various cardiovascular diseases (CVDs), noting that men and women often experience different symptoms, according to a new American Heart Association scientific statement published today in the Association’s flagship peer-reviewed journal, Circulation. The statement also highlights how...
GlyNAC supplementation reverses aging hallmarks in aging humans
by Homa Shalchi, Baylor College of Medicine Credit: Pixabay/CC0 Public Domain A randomized, double blind human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC—a combination of glycine and N-acetylcysteine—improves many age-associated defects in older humans and powerfully promotes healthy aging. This is relevant because until now, there have been...
Study unveils a global dysregulation of dopamine in mice with chronic inflammatory pain
by Ingrid Fadelli , Medical Xpress Microscopic image of the anterior cingulate cortex (ACC) used for the current experiment. The black lines are the stimulation electrodes that were used to evoke synaptic responses, while the white lines show the placement of the recording electrode that monitored the activity of the neurons. Image credit: Soroush Darvish-Ghane....
Treadmill exercise shown to improve Parkinson’s symptoms in mice
by Rush University Medical Center Credit: Debashis Dutta et al, Cell Reports (2022). DOI: 10.1016/j.celrep.2022.111058 Regular treadmill exercise helped improve Parkinson’s disease symptoms in mice in a recent study by researchers at RUSH University Medical Center. The results of the study were recently published in the Cell Reports. “We’re very excited about the results,” said Kalipada Pahan, Ph.D., Floyd...
How immune cells overcome exhaustion
by Technical University Munich MYB regulates the expression of genes that are critical for the function and maintenance of exhausted T cells. a–c, Congenically marked Mybfl/flCd4Cre (Myb-cKO) and Cd4Cre (control) P14 T cells were adoptively transferred into naive recipient mice, which were then infected with LCMV-Docile. Splenic P14 subsets were sorted at 7 dpi and processed for bulk RNA-seq....
Cellular waste may supercharge immune cell function
by Van Andel Research Institute Credit: CC0 Public Domain The immune cells that protect us from infection and cancer seek out a wide array of fuel sources to power their function—including some long thought to be cellular waste products. The findings, published today in Cell Metabolism, lay the foundation for future personalized dietary recommendations designed to supercharge...
Consuming green vegetables, supplements suppresses inflammatory bowel disease
by American Physiological Society Credit: CC0 Public Domain The dietary supplement chlorophyllin alleviates inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, according to researchers from the Center for Diabetes and Metabolism Research at Sichuan University in China and from Cedars Sinai Medical Center in Los Angeles. In addition, chlorophyllin significantly reduces mortality related to...
New method detects gut microbes that activate immune cells
by Cedars-Sinai Medical Center Credit: Pixabay/CC0 Public Domain Cedars-Sinai investigators have developed a method to help identify which human gut microbes are most likely to contribute to a slew of inflammatory diseases like obesity, liver disease, inflammatory bowel disease, cancer and some neurological diseases. The technique, described in the peer-reviewed journal Science Translational Medicine, uses a protein...