Among all the nationalities of the world, Cookware girls are definitely the most beautiful and appealing. There is a unique fashion sense and their physical features can potentially attract men. They also have a very good personality, helping to make them perfect life partners for European males. These young girls are considered to be smart,...
Month: <span>August 2022</span>
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COVID OUT clinical trial suggests metformin effective at reducing odds of serious outcomes for COVID-19 patients seeking early treatment
UNIVERSITY OF MINNESOTA MEDICAL SCHOOL Published in the New England Journal of Medicine, researchers — led by the University of Minnesota Medical School and School of Public Health — have found that metformin, a commonly prescribed diabetes medication, lowers the odds of emergency department visits, hospitalizations, or death due to COVID-19 by over 40 percent; and...
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Pathway uncovered for greatest lupus genetic risk factor, study shows
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN Researchers at Michigan Medicine have uncovered the molecular mechanism that drives the disease-causing effects of the most common genetic risk factor for lupus, a study suggests. Systemic lupus erythematosus is a common, incurable autoimmune disease that affects millions of individuals worldwide, with a particularly high prevalence among women. A...
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Key mechanisms of airway relaxation in asthma revealed in new study
UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER CLEVELAND–Many therapeutics for asthma and other obstructive lung diseases target the β2-adrenergic receptor (β2AR), a G protein-coupled receptor (GPCR) that rapidly supports airway relaxation when stimulated. Yet, overuse of these agents is associated with adverse health outcomes, including death, which has limited their utility as frontline therapies. Now, a...
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Reprogramming human skin cells into aged neurons to study neurodegenerative disorders
by Lund University HD-iNs exhibit neurite specific autophagy alteration. (A) Reduced BECN1 expression in HD-iNs compared to Ctrl-iNs using western blot (n = 10 replicates for control and n = 9 replicates for HD-iNs). (B) LC3B-II levels are significantly increased in the HD-iNs, while the LC3B-II/I ratio decreased compared to the healthy Ctrl-iNs (n = 6 replicates). (C–H) Representative images and...
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Misophonia is more than just hating the sound of chewing
by Jeff Grabmeier, The Ohio State University Credit: Pixabay/CC0 Public Domain Researchers for the first time have identified the parts of the brain involved in a less-commonly studied trigger of misophonia, a condition associated with an extreme aversion to certain sounds. The results, from Ohio State University scientists, suggest that one popular explanation of what...
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Researchers identify a key enzyme that controls white-to-brown fat conversion
by Jacqueline Mitchell, Beth Israel Deaconess Medical Center CUL2 controls PRDM16 protein stability and beige fat biogenesis. a, Immunoblotting of Flag-tagged PRDM16 protein in HEK293T cells co-expressing Myc-tagged cullin proteins or an empty vector (Vec). b, Immunoblotting of endogenous PRDM16 protein in inguinal adipocytes overexpressing (OE) Flag-tagged CUL2 or Vec. β-Actin was used as the loading control. c,...
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Study reveals sex differences in age-related loss of kidney function
by American Society of Nephrology Visual abstract. Credit: Journal of the American Society of Nephrology (2022). DOI: 10.1681/ASN.2022030323 Although more women than men have chronic kidney disease (CKD), more men develop kidney failure. In a study in the Journal of the American Society of Nephrology of a northern European population that sought to explain this contradiction, kidney function was...
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Potential of nigrosome imaging for earlier diagnosis of Parkinson’s disease
by Bettina Hennebach, Max-Planck-Institut für Kognitions With high-resolution MRI imaging it is possible to image the swallow-tail sign, which is located in the posterior third of the substantia nigra. Credit: MPI CBS A team of neurophysicists, led by Malte Brammerloh of MPI CBS, found evidence that the identification of a magnetic resonance imaging (MRI) sign...
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Modeling how MRSA bacteria spread on the body can enhance treatments
by Aalto University The observed decrease in MRSA carriage detection over time by body site and study arm compared with the decrease predicted by the model. In the trial, study subjects were in the education group or the decolonization group, which consisted of applying mupirocin to the nares, chlorhexidine mouthwash (CHG Oral) to the throat...