by Northumbria University, Newcastle Graphical abstract. Credit: Cell Reports Medicine (2022). DOI: 10.1016/j.xcrm.2022.100717 Newly published research carried out using synthetic human bone marrow cells is paving the way for the development of safer and kinder treatments for children with leukemia. Leukemia is the most common cancer in children under 15, with over 650 children and young adults...
Does gender-affirming hormone therapy affect markers of kidney health?
by American Society of Nephrology (ASN) Graphical abstract. Credit: Clinical Journal of the American Society of Nephrology (2022). DOI: 10.2215/CJN.01890222 Gender-affirming hormone therapy modifies body composition and lean muscle mass in transgender persons. A recent analysis published in the Clinical Journal of the American Society of Nephrology examined the effects of masculinizing and feminizing gender-affirming hormone therapy on markers...
Intranasal vaccination produces potent systemic immunity against HIV and SARS-CoV-2 in animal models
by Delthia Ricks, Medical Xpress Long-lived antigen-specific IgG and IgA plasma cells are established in mice following intranasal immunization with amph-protein, without induction of anti-PEG antibodies. BALB/c mice (n = 3 animals per group) were immunized i.n. with 5 µg amph-eOD mixed with 25 µg cdGMP adjuvant and boosted 6 weeks later with the same...
Cost now biggest turn-off to smoking
by University of Queensland 48% of Australians who successfully quit smoking in 2019 said their main motivation was the rising cost of cigarettes. Credit: Pexels Rising cigarette prices have overtaken health concerns as the biggest motivator for people to cut down or stop smoking. Researchers from The University of Queensland analyzed national survey data and...
Smartphone video motion analysis detects narrowed neck arteries that may lead to stroke
by American Heart Association Video recording and processing. A, Video recording setup. B, Original video recording. C, Video processing and highlighting the movements of every pixel in each frame. Credit: Journal of the American Heart Association (2022). DOI: 10.1161/JAHA.122.025702 Motion analysis of video recorded on a smartphone accurately detected narrowed arteries in the neck, which are a...
New drug candidate uses novel absorption method to target cancer cells in mice
by University of Michigan A model demonstrating how this type of novel drug is absorbed through the lymphatic system. Credit: Danielle Dobbs/Michigan Medicine A team of University of Michigan researchers is developing a new anti-cancer drug that is absorbed through the gut’s lymphatic system rather than blood vessels, potentially outmaneuvering the molecular signaling pathways that...
New mRNA cancer vaccine targets lymph nodes for stronger immune response
By Michael Irving August 16, 2022 A new mRNA cancer vaccine is designed to target the lymph nodes to induce a stronger immune response Depositphotos Researchers at Tufts University have created a new mRNA vaccine for cancer that’s designed to carry its cargo to the lymph nodes rather than the liver. Tests in mice showed...
New algorithm can track mental health through skin
ByAlejandra O’Connell-Domenech Parkinson’s disease patient, Arthritis hand and knee pain or mental health care concept with geriatric doctor consulting examining elderly senior aged adult in medical exam clinic or hospital Story at a glance Researchers at NYU’s Tandon School of Engineering were able to create a “novel inference engine” that can monitor brain activity via...
Researchers validate threshold for determining effectiveness of antidepressant treatment
by Lynda De Widt, Mayo Clinic Credit: Unsplash/CC0 Public Domain More than one-third of people diagnosed with major depressive disorder don’t respond sufficiently to specific antidepressant treatments. Patients often need to try different options until one is effective. To help arrive at the right prescription sooner, a research team led by Mayo Clinic has developed...
Proteins in cell-based particles could lead to early diagnosis and treatment of breast cancer metastasis
by National University of Singapore A working model for integrin αvβ1 in the tumor microenvironment. Credit: Journal of Extracellular Vesicles One woman is diagnosed with breast cancer every 14 seconds somewhere around the globe—based on data showing that an approximate 2.3 million women worldwide were newly diagnosed with breast cancer in 2020. In Singapore, it is...