IOS PRESS IMAGE: THE MODEL DIMENSIONS INCLUDE AMYLOIDOSIS (A), TAUOPATHY (T), PATHOPHYSIOLOGY (P), AND NEURODEGENERATION (N). THE DISEASE PROCESSES WITHIN THOSE DIMENSIONS PRODUCE A CLINICAL OUTPUT (O) INVOLVING VIGILANCE, SLEEP-WAKE CYCLE, COGNITIVE FUNCTIONS, AND ABILITIES IN THE ACTIVITIES OF DAILY LIVING. KEY: CSF, CEREBROSPINAL FLUID; PET, POSITRON EMISSION TOMOGRAPHY; EEG, ELECTROENCEPHALOGRAPHY; ERO, EVENT-RELATED EEG OSCILLATIONS;...
New insights on how some individuals with obesity can lose weight – and keep it off
UNIVERSITY OF OTTAWA IMAGE: CLOCKWISE, FROM TOP LEFT: DR. ROBERT DENT, DR. CHANTAL PILEGGI, DR. RUTH MCPHERSON, AND DR. MARY-ELLEN HARPER. CREDIT: UNIVERSITY OF OTTAWA For decades, there’s been a persistent one-size-fits-all approach to treating obesity: Embrace a diet that’s low in calories. Yet evidence shows that this diet-focused approach simply doesn’t work for a...
Prompt recognition and treatment found effective for lung disease in patients who received new drug for advanced cancer
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE Lung disease caused by a new drug for cancers—including metastatic or advanced breast cancer—can be effectively treated using approaches that focus on early detection and prompt management, according to a study published in ESMO Open on August 11, 2022. Using data from nine clinical trials, this study...
Vegetarian women are at a higher risk of hip fracture
by University of Leeds Credit: University of Leeds A study of over 26,000 middle-aged UK women reveals those with a vegetarian diet had a 33% higher risk of hip fracture compared to regular meat-eaters. University of Leeds research, published Thursday, August 11 in the journal BMC Medicine, investigated the risk of hip fracture in occasional meat-eaters; pescatarians, people...
Repurposed drug could help patients with motor neuron disease
by University of Edinburgh Credit: Unsplash/CC0 Public Domain A drug typically used to treat enlarged prostates and high blood pressure has shown promise as a potential new therapy for motor neuron disease (MND)—also known as amyotrophic lateral sclerosis (ALS)—according to a new study. MND is a group of rare diseases that destroy nerve cells known as motor...
Study on serotonin and depression sparks fierce debate
by Julien DURY Debates on the role of serotonin only illustrate how difficult it is to understand the biological and social workings of an illness as complex as depression. A controversy in the scientific community over recent claims anti-depressants can be ineffective at treating depression has highlighted the difficulties in understanding mental health conditions. One...
Children infected with a mild case of COVID-19 can still develop long COVID symptoms
by University of Texas Health Science Center at Houston Credit: Pixabay/CC0 Public Domain While research has revealed that children and adults hospitalized with COVID-19 are more susceptible to developing long COVID symptoms, a new study by researchers at UTHealth Houston found that children infected with COVID-19, but not hospitalized, still experienced long COVID symptoms up...
Study finds that sound plus electrical body stimulation has potential to treat chronic pain
by University of Minnesota A University of Minnesota Twin Cities-led team has found that electrical stimulation of the body combined with sound activates the brain’s somatosensory cortex, increasing the potential for using the technique to treat chronic pain and other sensory disorders. Credit: SONIC Lab, University of Minnesota A University of Minnesota Twin Cities-led team...
Gene therapy rescues malfunctioning inner ear hair cells that transduce sound
by Salk Institute From left: Short, intermediate and long hair stereocilia (green) of the inner ear that transduce sound in mice treated with increasing levels of EPS8 (magenta). The addition of more EPS8 results in stereocilia elongation. Credit: Salk Institute/Waitt Advanced Biophotonics Core Scientists from the Salk Institute and the University of Sheffield co-led a...
Not all in the genes: Are we inheriting more than we think?
by Walter and Eliza Hall Institute Epigenetic tags (orange and blue) on inactive DNA. Researchers say epigenetic tags could be passed onto offspring more often than previously thought. Credit: Still from WEHI.TV’s animation “X Inactivation and Epigenetics” by Etsuko Uno A fundamental discovery about a driver of healthy development in embryos could rewrite our understanding of...