by Vanderbilt University Medical Center Credit: Unsplash/CC0 Public Domain A clinical trial to test whether three proven smoking cessation treatments could also reduce alcohol intake found no differences between the medications, but the rates of behavior change for alcohol consumption and smoking were high in all treatment groups. Results suggest these medications could play an...
Down on Vitamin D? It could be the cause of chronic inflammation
by University of South Australia There’s a direct link between low levels of vitamin D and high levels of inflammation. Credit: Rebecca Wood Inflammation is an essential part of the body’s healing process. But when it persists, it can contribute to a wide range of complex diseases including type 2 diabetes, heart disease, and autoimmune...
LOCUSTS CAN ‘SMELL’ HUMAN CANCER CELLS
However, patients need not worry about locusts swarming their doctors’ offices. Rather, the researchers say this work could provide the basis for devices that use insect sensory neurons to enable the early detection of cancer using only a patient’s breath. “NOSES ARE STILL STATE OF THE ART. THERE’S REALLY NOTHING LIKE THEM WHEN IT COMES...
Phase II study of Durvalumab plus concurrent radiotherapy in unresectable locally advanced NSCLC
by International Association for the Study of Lung Cancer Credit: Pixabay/CC0 Public Domain Researchers from Japan today reported that the first phase II study to evaluate the efficacy and safety of durvalumab and concurrent curative radiation therapy for PD-L1-positive unresectable locally advanced non-small cell lung cancer without chemotherapy met its primary endpoint with tolerable adverse...
Fatigue, headache among top lingering symptoms months after COVID
by Medical College of Georgia at Augusta University Dr. Elizabeth Rutkowski. Credit: Augusta University Fatigue and headache were the most common symptoms reported by individuals an average of more than four months out from having COVID-19, investigators report. Muscle aches, cough, changes in smell and taste, fever, chills and nasal congestion were next in the...
SARS-CoV-2 spike mutation that ‘escapes’ killer T-cells generated by infection and vaccination
by Cardiff University Credit: Cardiff University U.K. scientists have highlighted a mutation in the spike protein of SARS-CoV-2 that allows the virus to evade important immune cells induced by infection and vaccines. The P272L Spike mutation first arose during the U.K.’s second wave of COVID-19, which began in September 2020, and has been pinpointed to...
‘Inside out’ signaling promotes tumor growth
by Will Doss, Northwestern University Pharmacological inhibitor of MLCK MW01-022AZ suppressed tumor inflammation and growth. a Schematic of LLC lung tumor implantation in C57Bl6 mice and MW01-022AZ treatment. b–d Effect of MW01-022AZ on LLC b gross tumor morphology (n = tumors from 6 mice) c tumor volume (n = 9 mice and d tumor weight at endpoint (21 days)...
Mayo Clinic Minute: Learning the ‘ABCDEs’ of melanoma
by Alex Osiadacz Credit: Wikimedia Commons/National Cancer Institute Melanoma is a type of skin cancer that develops in cells that produce your skin’s pigment. Regular skin checks can help you identify the warning signs and differentiate melanoma from noncancerous skin formations, according to the American Academy of Dermatology. Moles are a common skin growth, and...
Extending the shelf life of vaccines
by ETH Zurich Artistic rendering of the gels encapsulating a viral vaccine. Credit: ETH Zurich / Jonathan Zawada Nearly half of all vaccines go to waste. This is due to the logistical obstacles involved in transporting them to diverse regions of the world. Most vaccines require strict temperature regulation from the manufacturing line to injection...
Reinvigorating ‘lost cause’ exhausted T cells could improve cancer immunotherapy
by University of Pittsburgh An artist’s depiction of a T cell. Credit: NIAID During a battle with cancer, T cells can become exhausted and are no longer able to function properly. The early phase of exhaustion can sometimes be reversed with immunotherapy drugs, but once T cells become too exhausted, it had been thought that this...