by Anke Schlee, Max Planck Society Neuroanatomical patterns of schizophrenia. Credit: Koutsouleris Researchers have, for the first time, compared schizophrenia and frontotemporal dementia—disorders that are both located in the frontal and temporal lobe regions of the brain. The idea can be traced back to Emil Kraepelin, who coined the term “dementia praecox” in 1899 to describe...
One injection of a candidate monoclonal antibody (mAb) known as L9LS was found to be safe and highly protective in U.S. adults exposed to the malaria parasite, according to results from a National Institutes of Health Phase 1 clinical trial published in The New England Journal of Medicine. Additional clinical trials evaluating if L9LS can prevent malaria over six to 12...
Florida State University researchers have developed a promising strategy for producing therapeutic particles in stem cells that could help patients with neurological diseases such as stroke or multiple sclerosis. The technique developed by researchers from the FAMU-FSU College of Engineering and FSU College of Medicine combines three-dimensional growing platforms with a wave motion. The research was published...
MASSACHUSETTS INSTITUTE OF TECHNOLOGY IMAGE: WITH A NEW APPROACH, THE SCAR TISSUE (PICTURED) THAT USUALLY DEVELOPS AROUND MEDICAL IMPLANTS HAS A MORE ALIGNED ARCHITECTURE THAT ALLOWS DRUGS TO PASS THROUGH MORE EASILY. CREDIT: COURTESY OF THE RESEARCHERS CAMBRIDGE, MA — Implantable devices that release insulin into the body hold promise as an alternative way to...
OSAKA UNIVERSITY IMAGE: WE PROPOSE THAT MALIGNANT HYPERTHERMIA OCCURS WHEN RUNAWAY THERMOGENESIS IS CAUSED BY A HEAT-SENSITIVE CA2+-RELEASE CHANNEL (RYR1). ANESTHESIA IS KNOWN TO TRIGGER CA2+ RELEASE THROUGH MUTANT RYR1 VARIANTS, FACILITATING THERMOGENESIS IN MUSCLE CELLS (GRAY ARROWS). IN THE PRESENT STUDY, WE FOUND THAT APPLYING HEAT CAUSES CA2+ RELEASE THROUGH RYR1 BY A MECHANISM...
KECK SCHOOL OF MEDICINE OF USC Flavored oral nicotine products, which contain no tobacco but are not FDA-approved to help people quit smoking, are increasingly marketed and sold in the U.S., but researchers have never measured their use among U.S. teens. In a new study, published this week in the journal Pediatrics, researchers from the...
OKAYAMA UNIVERSITY IMAGE: NEW STUDY IDENTIFIES VESICULAR NUCLEOTIDE TRANSPORTER AS A NOVEL TARGET OF EICOSAPENTAENOIC ACID (EPA) AND HIGHLIGHTS THE MECHANISM UNDERLYING THE ANALGESIC EFFECT OF EPA. EPA POTENTLY ATTENUATES NEUROPATHIC AND INFLAMMATORY PAIN AND INSULIN RESISTANCE, WITH FEWER SIDE EFFECTS CREDIT: TAKAAKI MIYAJI FROM OKAYAMA UNIVERSITY Eicosapentaenoic acid (EPA) is an essential nutrient belonging...
UNIVERSITY OF KENT Researchers from the University of Kent in Canterbury, UK and the Goethe-University in Frankfurt am Main have identified new therapies for COVID-19 that could provide better protection against future variants and outbreaks. An international team led by Professor Martin Michaelis, Professor Mark Wass (both School of Biosciences, University of Kent), and Professor...
TEL-AVIV UNIVERSITY IMAGE: FROM LEFT TO RIGHT: PROF. HELENA FLORINDO, PROF. RONIT SATCHI-FAINARO, DR. RITA ACÚRCIO, PROF. RITA GUEDES CREDIT: ERIC SULTAN & UNIVERSITY OF LISBON. Researchers at Tel Aviv University and the University of Lisbon have jointly identified and synthesized a small molecule that could be a more accessible and effective alternative to an...
CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN Cystic fibrosis remains an incurable genetic disorder which impairs lung function and significantly reduces life expectancy. A new combination drug therapy which addresses the disorder’s underlying defects offers a promising new treatment approach. The use of this therapy had previously been limited to adolescents and adults. Designed to meet the highest...
