by American Academy of Neurology Credit: Pixabay/CC0 Public Domain People who have had bariatric surgery may have an increased risk of developing epilepsy, according to a study published in the September 28, 2022, online issue of Neurology. “Bariatric surgery, which involves altering your digestive system, has become a more common treatment for weight loss,” said study author...
by University of California, San Francisco Newly identified α2AAR agonists are analgesic without sedation.More than 301 million molecules were docked against the activated α2BAR. Experimental testing identified α2AAR agonists with diverse chemical scaffolds. The experimental structure of the ‘9087-α2AAR complex superposed closely to the computational prediction. The newly discovered agonists had efficacy in an in...
by University of Oxford Incidence rates by age band for major osteoporotic fracture in women and men with and without intellectual disability. Number of fractures per 10,000 person years by age. Filled circles represent age band specific incidence rates. Age bands are 1-year in children and 5-year in adults. The bars represent 95% CI. Credit: eClinicalMedicine (2022)....
by Melissa Rohman, Northwestern University An in vivo genome-wide CRISPR-Cas9 KO screen identifying CTC-promoting genetic factors. (A) Experimental design of the genome-wide CRISPR-Cas9 KO screen focused on CTCs. (B) Primary tumor growth curves of the immunocompromised mice subcutaneously transplanted with either the TKOv3-transduced PC-3M cells or the control cells (n = 3 for each group)....
In the early stages of the COVID-19 pandemic, we thought the coronavirus was everywhere—stuck to our cellphone screens, smeared on our mail, dangling from doorknobs, even clinging to our cereal boxes. But it wasn’t. Despite public health guidance suggesting surfaces be disinfected to stop the spread of COVID-19, the virus wasn’t significantly transmitted through inanimate surfaces...
Aspartate aminotransferase (AST) is an enzyme found mostly in the liver. AST is an enzyme important in amino acid metabolism. It is also present in the heart, brain, gall bladder, and other organs. If liver cells are damaged, AST may be released into the blood. A blood test can therefore detect the problem. It may...
by Institute for Basic Science The inflammatory response of RA causes autophagy in FLSs to produce putrescine, which intensifies inflammation of GABA and H2O2 through the MAO-B in the joint. In chronic inflammation, increased IL-1β passes through a loose blood-brain barrier and enters the brain. Increased IL-1β in the hippocampus causes cognitive impairment by activating astrocytes...
UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: ROB KNIGHT, PHD, IS A PROFESSOR IN THE DEPARTMENTS OF PEDIATRICS AT UC SAN DIEGO SCHOOL OF MEDICINE AND BIOENGINEERING AND COMPUTER SCIENCE AT UC SAN DIEGO JACOBS SCHOOL OF ENGINEERING. CREDIT: UC SAN DIEGO HEALTH SCIENCES An international team of scientists, co-led by researchers at the University...
UNIVERSITY OF BATH A new academic study demonstrates for the first time that scheduling medical appointments later in the week increases patient attendance by over 10 percent. Missed appointments are a long-standing challenge for the NHS, increasing costs and reducing already strained services. Research has shown missing appointments can have a deadly impact on patient health. NHS analysis...
FRONTIERS The neurohormone oxytocin is well-known for promoting social bonds and generating pleasurable feelings, for example from art, exercise, or sex. But the hormone has many other functions, such as the regulation of lactation and uterine contractions in females, and the regulation of ejaculation, sperm transport, and testosterone production in males. Now, researchers from Michigan...
