by Roswell Park Comprehensive Cancer Center Credit: CC0 Public Domain A therapy made of immune system T cells engineered to target a somewhat enigmatic cell protein called GPRC5D antigen produced impressive results in its first clinical trial in patients with multiple myeloma, researchers at Memorial Sloan Kettering Cancer Center (MSK), Dana-Farber Cancer Institute and Roswell...
by Nanjing University School of Life Sciences Evaluation of the activity of TNF-α siRNA-encapsulating sEVs in an ex vivo model. a Schematic of the experimental design. Acute UC was induced in male BALB/c mice by replacing their drinking water with a 2.5% DSS solution for 7 days. DSS mice were intravenously injected with 5 mg/kg CMV-scrR...
by University of Bristol Credit: Pixabay/CC0 Public Domain Long-term antidepressant use may double the risk of heart disease, finds the most comprehensive epidemiological study to date to investigate the health consequences from using the medication over ten years. The University of Bristol-led study, published in the British Journal of Psychiatry Open, analyzed data on over 200,000 people....
by Medical University of South Carolina Immunofluorescence images showing healthy (left) and scleroderma (right) lung. The scleroderma lung shows reduced levels of Cathepsin L (green) and increased levels of fibroblast activation marker (red). Image courtesy of Joe Mouawad, Medical University of South Carolina. Credit: Joe Mouawad, Medical University of South Carolina Much of the research...
by MATTHEW PERRONE Credit: Unsplash/CC0 Public Domain A much-debated drug for Lou Gehrig’s disease won U.S. approval Thursday, a long-sought victory for patients that is likely to renew questions about the scientific rigor behind government reviews of experimental medicines. The Food and Drug Administration approved the drug from Amylyx Pharmaceuticals based on results from one small, mid-stage...
by University of Cambridge Credit: Pixabay/CC0 Public Domain A new report highlights the advances and challenges in prevention, clinical care, and research in traumatic brain injury, a leading cause of injury-related death and disability worldwide. The report, by the 2022 Lancet Neurology Commission, has been produced by world-leading experts, including co-lead author Professor David Menon...
Max Kozlov The fungus Candida — shown here growing under laboratory conditions — has been found in some tumour samples. Credit: Nicolas Armer/dpa/Alamy For years, evidence has been mounting that bacteria are linked to cancer, and sometimes even play a crucial part in its progression. Now, researchers have found a similar connection with another type...
by Emory University Credit: Unsplash/CC0 Public Domain People with the inherited disorder myotonic dystrophy (DM) often experience excessive daytime sleepiness and fatigue, as well as altered responses to anesthetics that can put them at risk for complications when hospitalized. Emory researchers, in collaboration with colleagues at Columbia and University of Florida, now have evidence from...
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN Of the 37 million Americans with diabetes, up to 50% may end up with nerve damage, or diabetic neuropathy, that can be painful and disabling. While some medications can reduce pain, scientists continue searching for factors that cause patients to develop diabetic neuropathy – to identify ways to reduce...
by Jeff Hansen, University of Alabama at Birmingham Credit: Pixabay/CC0 Public Domain Macrophages are immune cells that engulf and digest pathogens, cancer cells or cellular debris. The kidneys—like other tissues in the body—contain kidney resident macrophages, or KRMs, from the time of birth. These KRMs protect the kidney against infection or injury and help maintain tissue...
