by Massachusetts General Hospital Credit: Unsplash/CC0 Public Domain Fentanyl is used to supplement sedation and to relieve severe pain during and after surgery, but it’s also one of the deadliest drugs of the opioid epidemic. In research conducted by investigators at Massachusetts General Hospital (MGH) and published in PNAS Nexus, tests of the brain’s electrical activity revealed...
by Mallory Locklear, Yale University Credit: Michael S. Helfenbein An enzyme found in the brain acts as a major regulator of body weight, Yale researchers have discovered. In a new study, they found that removing the enzyme from neurons in a part of the brain known as the hypothalamus led mice to gain weight and...
by Brown University Images from the paper show indicators of neurodegeneration in the locus coeruleus part of the brain. This is reflected by purple neurons surrounded by activated green glial cells in the animal model of GPT2 Deficiency (“GPT2-null”). Credit: Brown University The locus coeruleus is among the first brain regions to degenerate in Alzheimer’s...
by University of British Columbia Visual Abstract. Efficacy of a commercial weight management program compared with a do-it-yourself approach. Credit: JAMA Network Open (2022). DOI: 10.1001/jamanetworkopen.2022.26561 For people trying to improve their health and lose weight by themselves—privately tracking and journaling meals and exercise—new research from UBC Okanagan suggests it is time to call in the professionals. Dr....
by Wellcome Trust Sanger Institute Credit: CC0 Public Domain An international consortium of researchers has identified genetic variants in 10 genes that elevate a person’s susceptibility to Crohn’s disease, a form of inflammatory bowel disease. Led by researchers from the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard, the study is the largest...
BY AMY CAMPBELL, MS, RD, LDN, CDCES | AUGUST 23, 2022 Numbers play a big role in managing diabetes. For example, monitoring blood sugars, either with a meter or a CGM (continuous glucose monitor), gives you information on where your blood sugars stand at a particular point (or points) in time. Getting your cholesterol measured...
Schizophrenia is a fairly uncommon condition, affecting around 0.25–0.64% of people in the United States. It can have a profound impact on a person’s life, as well as the lives of those around them. Schizophrenia is a lifelong condition, but treatment can help manage the symptoms. This article will look at the causes and symptoms...
The paper in Cell Reports details the cooperation of two known cancer genes, Arid1a and Kras, and how they disable tumor suppressor activity. When both genes are mutated—particularly Arid1a—the pathways that usually shut down tumor activity cannot perform. The goal is to use the data to find drugs that could restore the normal function of a mutated Arid1a, to...
The research arm of the U. S. Army has awarded Case Western Reserve University blood surrogate pioneer Anirban Sen Gupta a four-year, $2.5 million grant to advance and optimize his latest nanotechnology to stop bleeding from battlefield injuries. Sen Gupta and his team devised the new technology called “SanguiStop.” It allows a clot-promoting enzyme called thrombin to be intravenously...
MASSACHUSETTS EYE AND EAR INFIRMARY IMAGE: OTODX IS CURRENTLY BEING EMPLOYED IN A PROTOTYPE DEVICE PAIRED WITH A SMARTPHONE APP. THE DEVICE ACTS AS A “MINI OTOSCOPE” THAT WOULD FIT OVER THE PHONE’S CAMERA AND ALLOW CLINICIANS TO TAKE PHOTOS OF THE INSIDE OF A CHILD’S EAR, UPLOAD THEM DIRECTLY TO THE APP AND RECEIVE...
