by University of Edinburgh Credit: Unsplash/CC0 Public Domain Medication that lowers blood pressure is equally effective if taken in the morning or evening, a large clinical trial has found. This overturns previous research that suggested blood pressure-lowering medication may be more effective if taken in the evening. Blood pressure-lowering medications are among the most widely prescribed...
Improved understanding of early spinal cord development paves the way for new treatments
by Rebekah McBride, University of Wisconsin-Madison Addition of BMP7 during neuronal differentiation further dorsalizes postmitotic population. (A) Timeline of dorsal differentiation from H120-NMPs, with BMP7 added during neuronal differentiation phase from days 14 to 19. (B to G) Immunostaining in day 19 postmitotic cultures shows that DAPT treatment rapidly converts progenitors to dorsally shifted postmitotic phenotypes...
New machine-learning technique for classifying key immune cells has implications for a suite of diseases
by Trinity College Dublin Overview of experimental work. Image created using biorender.com. Credit: eLife (2022). DOI: 10.7554/eLife.77373 Researchers from Trinity College Dublin have developed a new, machine learning-based technique to accurately classify the state of macrophages, which are key immune cells. Classifying macrophages is important because they can modify their behavior and act as pro- or anti-inflammatory agents...
Test for carbon monoxide poisoning is unreliable and should not be used
by European Society for Emergency Medicine Pulse oximeter placed on the fingertip to measure a patient’s pulse and oxygen saturation. Credit: Mathilde Papin / European Society for Emergency Medicine Pulse oximetry is an unreliable method for spotting people suffering with carbon monoxide poisoning and it should not be used for this purpose, according to a...
Strict parenting may hard-wire depression risk into a child’s DNA
by European College of Neuropsychopharmacology Credit: Pixabay/CC0 Public Domain Strict parenting can alter the way the body reads the DNA of children. These changes can effectively become “hard-wired” to the DNA of those children who perceive their parents as harsh, increasing their biological risk for depression in adolescence and later life. Presenting the work at...
Structure of adult brain, previously thought to be fixed, is changed by treatment
by European College of Neuropsychopharmacology Representative map of the affected connections in the brain. The number of these connections increased after treatment. Credit: Jonathan Repple Scientists believe that the structure of the adult brain is generally rigid and incapable of rapid changes; now new work has shown that this is not true. German researchers have...
Fatty tissue surrounding intestinal tracts of mice found to help eject gut-infesting worms
by Bob Yirka, Medical Xpress The graphic is a schematic summary of the main findings of the paper, where changes in mesenteric adipose tissue during infection are highlighted. Credit: Agnieszka Kabat and Edward Pearce A team of researchers at the Max Planck Institute for Immunobiology and Epigenetics, working with colleagues from the Washington University School...
A sound approach for effective gene therapy delivery to the brain
by Beth Miller, Washington University School of Medicine in St. Louis In new research, Hong Chen and her team developed an intranasally delivered gene therapy method that had comparable or better outcomes than existing methods while having minimal effect on the body’s other organs. Credit: Chen lab Researchers have been experimenting with different ways to...
NEIDL Researchers Refute UK Article about COVID Strain
OCTOBER 17, 2022 Boston University is refuting a series of misleading claims about research at the University’s National Emerging Infectious Diseases Laboratories (NEIDL). The reports, which first appeared on Monday in the United Kingdom’s Daily Mail, claimed researchers at the lab had “created a new deadly COVID strain.” In a statement Monday afternoon, BU called the reporting,...
Addiction drug shows promise lifting long COVID brain fog, fatigue
By Julie Steenhuysen Lauren Nichols, who has long COVID, takes a break and rests in a lounge bed in the office in her home in Andover, Massachusetts, U.S., August 3, 2022. REUTERS/Lauren Owens Lambert/File Photo CHICAGO, Oct 18 (Reuters) – Lauren Nichols, a 34-year-old logistics expert for the U.S. Department of Transportation in Boston, has been...