by Fabio Bergamin, ETH Zurich The role of miR-7 in Sim1 neurons to regulate mammalian energy homeostasis and neuroendocrine function. In mice, hypothalamic expression of miR-7 is regulated by metabolic state. In humans, variants in the locus encompassing miR-7 are associated with reduced expression of HNRNPK/MIR-7-1. miR-7 regulates the expression of the noncoding RNAs Cyrano...
by Hayley Jarvis, Brunel University Comparison of K562-t(7;12) transcriptional landscape with t(7;12) patient signatures. A 177-gene signature of t(7;12)-patient gene expression extrapolated from published microarray and RNA sequencing datasets by comparison with other pediatric AML subtypes. The Venn diagram shows the 177 intersect genes. B 121-gene t(7;12)-specific signature inferred by comparisons of gene expressions of...
by The Francis Crick Institute Credit: Pixabay/CC0 Public Domain Monoclonal antibody therapies continue to neutralize SARS-CoV-2 variants currently in circulation, including omicron BA.4/5, according to laboratory findings from the Francis Crick Institute and the National Institute for Health Research (NIHR) UCLH Biomedical Research Center, published as a research letter in The Lancet. In the U.K., monoclonal antibodies are part of an important strategy to protect clinically...
by University of Bristol Enhanced Ca2+ entry through L-type channels results in augmentation of currents underlying medium and slow AHPs in hippocampal CA1 pyramidal neurons expressing 4R0N-tau. (Ai,Bi) Membrane current evoked following a depolarizing voltage step to + 10 mV (100 ms duration) in absence (black trace) and presence (gray trace) of nimodipine (10 μM) in cells expressing either EGFP only...
by Emily Velasco, California Institute of Technology Phase sensitivity of Diff-CUP. a Spatiotemporal interferograms of a 2.6-ns EMP in the LN crystal captured by the streak camera and simulated by the electric field and phase distribution model, and the corresponding temporal phase averaging over the x direction. Horizontal scale bars, 300 µm. Vertical scale bars, 500 ps....
by International School of Advanced Studies (SISSA) Prions. Credit: National Institute of Health Prion diseases, such as bovine spongiform encephalopathy (“mad cow disease”), are lethal neurodegenerative infectious diseases that affect humans and other mammals and for which there is currently no cure. These diseases are caused by the accumulation of prions, which are misfolded versions of...
by Linköping University Lech Kaczmarczyk and Susanne Bauer study changes in the brain in very early stages of neurodegenerative diseases. Credit: John Karlsson/Linköping University Many changes take place in the brain long before symptoms appear. This has been shown in mice in two studies of prion diseases in which the brain gradually deteriorates. The results...
Credit: Unsplash/CC0 Public Domain Rugby chiefs must take urgent action to reduce head injuries after a study indicated that former international players are 15 times more likely to develop motor neurone disease, researchers said Tuesday. Academics, who studied a cohort of former Scottish internationals, found that, overall, the ex-players were about 2.5 times more likely...
by Hong Kong Baptist University A research team led by Professor Cai Zongwei (left) and Dr Yang Zhu (right) has revealed the association between rapidly fading antibody levels in some recovered COVID-19 patients and a high plasma concentration of a metabolite called gly-pro and its producing enzyme. Credit: Hong Kong Baptist University A study led...
by Mike Snider Credit: CC0 Public Domain Researchers have provided more evidence that eating earlier in the day might be good for you—and eating all of your meals within a 10-hour window could be healthier, too. The takeaway from this latest wave of research on eating? Eat breakfast and try to confine your meals closer...
