by The Spanish National Cancer Research Centre Efficient Trf1 deletion in lung fibroblasts upon tamoxifen administration. a Generation of the conditional knockout mouse model in which Trf1 was deleted in fibroblasts using the Cre recombinase driven by the Col1a2 promoter. Trf1lox, KFPLox-LSL-Lox, and Col1a2-CreERT2 alleles are depicted before and after Cre-mediated excision. b Tamoxifen (TMX)...
Cavity-causing microbe “superorganisms” grow limbs to leap across teeth
By Michael Irving October 05, 2022 Microscope images of the newly discovered moving “superorganisms,” made up of bacteria (green) attached to filaments of fungus (blue)Penn Dental Medicine If you needed more motivation to brush your teeth regularly, this could do the trick. Scientists have discovered that cavity-causing bacteria and fungi in saliva can team up...
How our eyes can change colour throughout our lives
By Martha Henriques 29th September 2022 Through apparently spontaneous change or through mishap or illness, our eyes can change colour in surprising ways. The first pictures of the new-born baby that flashed up on our family chat showed a charming, surprised-looking face with wide, slate-grey eyes – similar in shape to his father’s brown eyes,...
16 Common Causes of Night Sweats — and What to Do About It
Written by Cherilyn Cecchini, MD | Reviewed by Katie E. Golden, MDPublished on September 19, 2022 Key takeaways: Waking up in a pool of sweat is uncomfortable. But it’s not always a cause for concern. It’s usually due to a warm room, heavy sleepwear, or too many covers on your bed. Other common causes of...
Three years after clinical trial, ketamine provides hope for severely depressed
by Thomas Curwen One 10 ml vial of 1000 mg ketamine. Credit: Psychonaught/Wikipedia Patients arriving at Dr. Philip O’Carroll’s Newport Beach office for their first ketamine treatment are in pain and often lost. They have visited other doctors, tried other solutions and are ready for what is considered a last resort. They are led to...
Radiotracer that detects important contributor to neurological diseases is tested for the first time in humans
by Massachusetts General Hospital [18F]3F4AP in human subjects. A Representative whole-body maximum intensity projections of a male and a female participant at different time points. B Representative brain images of a male and a female participant. C Averaged time-activity curves of selected organs. Credit: Pedro Brugarolas et al, European Journal of Nuclear Medicine and Molecular Imaging (2022)....
Biological pathways provide evidence for how to overcome barriers limiting cancer immunotherapies
by UNC Lineberger Comprehensive Cancer Center Credit: Unsplash/CC0 Public Domain Researchers at UNC Lineberger Comprehensive Cancer Center have found a possible way to overcome barriers that block effective anti-cancer immune responses, thereby opening the potential for more effective immunotherapies in people. The findings are published in Nature. An unfavorable immune environment immediately surrounding a tumor cell...
Do you act before you think or think before you act?
by Iqbal Pittalwala, University of California – Riverside Credit: Unsplash/CC0 Public Domain Will you read this news release now or decide to read it later? “Precrastination,” defined as the tendency to expend extra effort to get things done as soon as possible, could explain what you will do. We have all probably precrastinated, that is,...
Study links omega-3s to improved brain structure, cognition at midlife
by University of Texas Health Science Center at San Antonio Credit: CC0 Public Domain Eating cold-water fish and other sources of omega-3 fatty acids may preserve brain health and enhance cognition in middle age, new evidence indicates. Having at least some omega-3s in red blood cells was associated with better brain structure and cognitive function...
Researchers discover a new type of RNA that inhibits a broad range of viral infections
by Lindsay Brownell, Harvard University Graphical abstract. Credit: Molecular Therapy – Nucleic Acids (2022). DOI: 10.1016/j.omtn.2022.08.031 RNA is often described as the single-stranded cousin of DNA, the double-stranded molecule that makes up the genomes of all living organisms. Many types of non-living viruses, however, carry their genetic information in a double-stranded form of RNA (dsRNA). When the...