by Torsten Fischer, Helmholtz Association of German Research Centres Researchers can now better understand the system of lymph nodes and their blood vessels. Credit: Paul Schütz When our immune system runs, it sets in motion antibodies, white blood cells and phagocytes. But all the details of how this works are not yet understood—specifically, in the...
by Northern Arizona University Overview of protocol. a, Design of a peptide library begins with a set of target protein sequences. An informatic approach (such as the combined sliding-window/set-cover algorithm described in the ‘Design of peptide-encoding oligonucleotides’ section of ‘Experimental design’) is then used to design a library of peptides of a user-defined length that...
by Frontiers Credit: Unsplash/CC0 Public Domain Alzheimer’s disease can remain undetected until it is too late to treat. Large-scale screening programs could help to detect early-stage disease, but current diagnostic methods are too cumbersome and expensive. Now, a new study is the first to identify formic acid as a sensitive urinary biomarker that can reveal...
by Radiological Society of North America Ultrasound images depicting hydrodissection procedure in a patient with carpal tunnel syndrome. (A) Needle placed below the median nerve with fluid dissecting the nerve from the underlying flexor tendons (green star). (B) Needle placed above the median nerve with fluid dissecting the nerve away from the flexor retinaculum (yellow...
by The Mount Sinai Hospital Cst7 (yellow) is a Plaque Induced Gene (PIG) and its expression is specific to plaques in the INPP5D knockdown mouse (right), vs an AD mouse with normal levels of INPP5D (left). Credit: Emilie Castranio, PhD, postdoctoral fellow at the Icahn School of Medicine at Mount Sinai and co-first author of...
by Children’s Hospital of Philadelphia Credit: Unsplash/CC0 Public Domain Researchers at Children’s Hospital of Philadelphia (CHOP) have discovered a specific genetic variant in SCN1A, the most common genetic epilepsy, that leads to an earlier onset of epilepsy, with clinical features distinct from other epilepsies. The researchers also identified a potentially effective treatment strategy. The findings...
by Lori Dajose, California Institute of Technology Gut microbiota reduce the incentive salience of a high-sucrose reward and decrease activity in mesolimbic brain regions linked to reward behaviors (A) Schematic illustrating timeline of fixed-ratio 1 (FR1) training and progressive ratio (PR) breakpoint testing. (B) High-sucrose pellets obtained during daily FR1 training sessions of VEH (n =...
by Olivia Dimmer, Northwestern University Reported Clinical Actions After a Definitive Genetic Diagnosis A, Respondents reported whether the genetic finding influenced a change in clinical management of the patient. B, Those who indicated “yes” selected all of the changes that were implemented or recommended (a patient could have >1 recommendation reported and is counted in...
by Delthia Ricks, Medical Xpress In vitro characterization of in vivo / ex vivo-derived 4T1 metastatic cell lines. (A) Schematic representation of the procedure used to generate the 4T1-BM2 metastatic cell line. (N=2, n=10). (B) Lung and brain metastatic clones of 4T1-T2, 4T1-LM2 and 4T1-BM2 cells orthotopically injected in BALB/c mice. N=2-3, n=8-10. (C) Macroscopic...
Chris Young Created: Nov 29, 2022 10:11 AM EST INNOVATION Scientists have developed a programmable, wireless spatial light modulator that can manipulate light at the wavelength scale with orders-of-magnitude faster response than existing devices. An international group of researchers, led by a team at MIT, spent more than four years developing technologies for high-speed optical...
